Would you use alternative management in a chronic phase CML with a 3 way translocation between chromosome 9, 22 and 7?  

Variant Philadelphia chromosome translocations that involve a third or fourth chromosome in addition to chromosomes 9 and 22 are seen in around 5% of patients with CML. They are considered simple translocations if involved chromosome 22 in addition to a chromosome other than 9, or complex if involve...