Would you use SBRT to treat a >5cm NSCLC with chest wall invasion in a medically inoperable patient?  

This is a very relevant and interesting question as the patterns of practice and indications for lung SBRT continue to evolve. It also fits in nicely with two recent retrospective reviews we conducted at the Cleveland Clinic using our 10-year old lung SBRT data registry. Addressing the first compone...

There are also more modestly hypofractionated regimens described which @Laurie E. Gaspar alludes too. Those are also an option in this case. The CALGB hypofractionated regimen of 70Gy in 20 fractions has local control rates that were similar to early SBRT experiences. (CALGB 39904 Bogart et al ...

Yes I agree, an SBRT dose regimen (higher dose per fraction and a more localized treatment) can bring better results (local control /pain reduction) than a standard conventional fractionation scheme. Dose to the chest wall should be well documented through to avoid chest wall toxicity.