Are there any patient characteristics that make you change fractionation when treating per STAMPEDE?

I generally favor 55/20 for patients where I am treating just the prostate in the setting of non-oligometastatic disease, and not treating the other metastases. It is a relatively low dose and I can't think of a scenario where I would turn the dose down for any patient factors. 6 Gy x 6 is very reas...

I utilize 55 Gy in 20 fractions as is currently recommended by the NCCN and was used on STAMPEDE (in addition to a fractionation schedule of 36 Gy in 6 weekly fractions, which was utilized in ≈ ½ of the participants, Parker et al., PMID 30355464). RT at these dose schedules was shown to produce very...