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Are you comfortable with using NSAIDs in a patient on methotrexate for inflammatory arthritis?
Given the drug-drug interaction, do you monitor more closely for methotrexate toxicity, counsel on symptoms of methotrexate toxicity, or avoid the combination altogether?
Answer from: at Academic Institution
Yes, there is a theoretical drug-drug interaction here. However, I don’t avoid using the combination altogether. In certain patients, I am still using NSAIDs in combination with MTX. However, not uncommonly, the patient’s pharmacist may warn the patient of this potential interaction, and...
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Answer from: at Community Practice
I agree 100% with Dr. @Emilio Gonzalez. We also need to remember that the drug interactions between NSAIDs and MTX were with high doses used in oncology. Numerous studies looking at RA low-dose MTX are not associated with increasing MTX levels, such as Combe et al., PMID 7788170 and Hübner...
Comments
at Emory Health
MTX/NSAID calls drive me crazy when they happen. ...
MTX/NSAID calls drive me crazy when they happen. ...