Are you comfortable with using NSAIDs in a patient on methotrexate for inflammatory arthritis?  

Yes, there is a theoretical drug-drug interaction here. However, I don’t avoid using the combination altogether. In certain patients, I am still using NSAIDs in combination with MTX. However, not uncommonly, the patient’s pharmacist may warn the patient of this potential interaction, and...

I agree 100% with Dr. @Emilio Gonzalez. We also need to remember that the drug interactions between NSAIDs and MTX were with high doses used in oncology. Numerous studies looking at RA low-dose MTX are not associated with increasing MTX levels, such as Combe et al., PMID 7788170 and Hübner...