Are you requiring markers other than LTE4 to be elevated to diagnose MCAS?

There has been new data to suggest LTE4 is not the best urinary marker of mast cell activation, so are you requiring other markers to be elevated to diagnose MCAS?

Answer from: at Academic Institution

The commercially available biomarkers to assess systemic mast cell activation in vivo include serum tryptase, N-methyl histamine (major metabolite of histamine), various forms of 11-beta-PGF2-alpha (PGD2 metabolite), and LTE4 (major metabolite of LTC4). The metabolites of these small molecules are m...

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Are you requiring markers other than LTE4 to be elevated to diagnose MCAS?

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