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Topics:
Allergy & Immunology
•
Mast Cell Disorders
Does a patient with known systemic mastocytosis need a bone biopsy of lytic vertebral lesions to rule out other etiologies?
Related Questions
Do you recommend patients try antihistamines such as oral ketotifen that are not approved in the US but are approved in the EU for MCAS if currently available formulations have not been effective?
How do you counsel a patient on returning to the care of their PCP when a workup for MCAS has been unrevealing, but the patient insists that they have a mast cell disorder because they respond to antihistamine therapy?
What is the overlap of POTS and Ehlers-Danlos with MCAS?
Do you diagnose MCAS if a patient is concurrently on drugs known to cause non-specific mast cell degranulation?
Is there any role for immunosuppressive/immunomodulatory therapy used off label for mast cell activation syndrome besides omalizumab?
Are you requiring markers other than LTE4 to be elevated to diagnose MCAS?
Do you favor 24 hour urinary metabolites over random urine collection when screening for MCAS?
How do you reassure families that no allergy testing is needed for urticaria?
What is your preferred biologic in children and adolescents with T2 high asthma?
What treatment options do you consider if eosinophilia with end organ dysfunction persists with q8 week dosing of benralizumab and you can't obtain approval for q4 week dosing?
