Is there any indication for IVIG in immunocompromised patients with only decreased IgM and/or IgA levels?  

Nope. IVIG preparations contain IgG not IgA or IgM. Low serum IgA may or may not be associated with low IgA levels in mucosal surfaces leading to a risk of local infections. Low levels of one or both may be asymptomatic but in the right setting might suggest a need for evaluation of plasma cell dysc...

I agree with Dr. @Sigal but would add the caveat that we should consider the patient's condition. If the patient is having signs/symptoms of increased infection, one should evaluate specific antibody levels and/or vaccine responses before dismissing the possibility that IgG replacement or augme...

The initial question is somewhat vague in reference to using the term "immunocompromised". That is a clinical, not a laboratory diagnosis. With few exceptions, low (as opposed to absent) levels of any Ig class are, in and of themselves, not diagnostic of a clinically relevant immune-compromised stat...

Very interesting convo @Melvin Berger. I inherited patients with this scenario, and was like hmm, I don't think these patients need immune globulin replacement therapy, but they came from providers who diagnosed them with IgG subclass deficiency. Also, probably had non-allergic rhinitis as opposed t...