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Medical Oncology • Immunotherapy
At what doses of steroids would you feel it's acceptable to either initiate or resume checkpoint inhibitors?
Particularly if steroids are used for non-immunotherapy toxicities (COPD exacerbation, brain edema, autoimmune diseases to name a few) -- when do you feel you are not compromising efficacy?
Answer from: Medical Oncologist at Academic Institution
In clinical trials, most trials did not allow patients to receive therapy if they were receiving 10 mg or more of prednisone (or equivalent). In clinical practice, patients on a higher dose of steroids are often interested in receiving therapy. Although some data indicate worse outcomes among patien...
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