At what point do you prescribe duloxetine for the treatment of AIMS (aromatase inhibitor induced musculoskeletal syndrome)?  

Results from the SWOG-1202 clinical trial were recently presented in the SABCS 2016 conference in December. (Editor note: Full publication in JCO, 11/2017). Duloxetine is a SNRI approved to treat depression, anxiety, neuropathic pain, and chronic pain syndromes including fybromyalgia. This study enr...

I agree completely. I generally use duloxetine for AIMSS after I have already tried switching a patient from her first AI to the second one. Although not everyone tolerates duloxetine, in my experience the majority do and get a good response in terms of reduced pain, which enables them to continue t...