At what PSA level would you consider restaging a patient who was treated with ADT and radiation and had undetectable PSA?  

The criteria for defining PSA relapse after radiation therapy remains the Phoenix criteria (see Roach et al., PMID 16798415), which is essentially nadir + a 2 point rise in serum PSA. Thus, a patient who achieves an undetectable PSA on ADT/RT but then experiences a PSA rise would not meet PSA relaps...

After radiotherapy and androgen deprivation, I order testosterone with surveillance PSAs until the testosterone level plateaus after recovery from androgen deprivation. PSA will rise as testosterone recovers, and more often than not, PSA rises are benign. In my opinion, there generally is no need fo...