Can a dihydropyridine calcium channel blocker (CCB) like amlodipine be prescribed in addition to a non-dihydropyridine CCB such as diltiazem or verapamil for treating hypertension?
Answer from: at Community Practice
Yes, with extreme caution.
Diltiazem and Verapamil are CYP450 inhibitors, which can interfere with the metabolism of many medications (commonly statins and calcineurin inhibitors), but also can increase levels of nifedipine and presumably other dihydropyridine CCBs, like amlodipine.
Diltiazem or v...
Comments
at Centro Cardiovascular I case of contraindication for B Blocker. I use th...
Why would you use two antihypertensive medications of the same class? There are so many other options available.
I think as a last resort, perhaps. Most of the time I have seen this combination used by other physicians. It was not really necessary.
Now in true resistant hypertensive patients,...
Dihydropyridine CCB, such as amlodipine, block only peripheral calcium channels, whereas the non-dihydropyridines, like diltiazem, also block the central (cardiac, AV node) channels, which confers them the rate-slowing say during AF. These agents help hypertension by blocking the peripheral calcium ...
I never use it especially in the population that I take care of. As a geriatric cardiologist, I tend not to use verapamil/diltiazem (due to their side effects and drug interactions) unless I have other reasons or they were already taking them. But not in conjunction with amlodipine/nifedipine. I tak...
Comments
at Nephrology Associates Of South Miami Pa I wrote a case report in 1991 in the Southern Medi...
at Lohe And Hasni Medical Group All the time and successfully: Sica, PMID 11588412
I case of contraindication for B Blocker. I use th...