Can a dihydropyridine calcium channel blocker (CCB) like amlodipine be prescribed in addition to a non-dihydropyridine CCB such as diltiazem or verapamil for treating hypertension?
Answer from: at Community Practice
Yes, with extreme caution.
Diltiazem and Verapamil are CYP450 inhibitors, which can interfere with the metabolism of many medications (commonly statins and calcineurin inhibitors), but also can increase levels of nifedipine and presumably other dihydropyridine CCBs, like amlodipine.
Diltiazem or v...
Comments
at Centro Cardiovascular I case of contraindication for B Blocker. I use th...
Why would you use two antihypertensive medications of the same class? There are so many other options available.
I think as a last resort, perhaps. Most of the time I have seen this combination used by other physicians. It was not really necessary.
Now in true resistant hypertensive patients,...
I case of contraindication for B Blocker. I use th...