Please select the option that best describes you:
Topics:
Hematologic Malignancies • Medical Oncology • Myelodysplastic Syndromes • Internal Medicine • Hematology
Can a patient with MDS have ring sideroblasts in the absence of mutation such as SF3B1?
Answer from: at Community Practice
Yes, < 50% of MDS RS have SF3B1 mutation by NGS. Malcovati et al., PMID 32347921
Sign in or Register to read more
Answer from: Medical Oncologist at Community Practice
Absolutely! While MDS with ringed sideroblasts and SF3B1 denote a special subset of MDS with ringed sideroblasts, they can also be seen with other spliceosome mutations (SRSF2, U2AF1 or ZRSR2). In one analysis, only 1.5% of patients with MDS with low blasts and ringed sideroblasts lacked a spli...