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Can docetaxel be safely given to patients with hyperbilirubinemia from Gilbert’s syndrome?
Is dose modification of docetaxel necessary with Gilbert's when giving TCHP?
Answer from: Medical Oncologist at Community Practice
Docetaxel can be safely administered at full doses in patients with Gilbert's Syndrome. These patients usually have a variant in the UGT1A1 gene. While it can cause issues with some oncologic therapies (especially ones that rely on UGT-1A - the classic being irinotecan), it does not seem to affect t...
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