Can trastuzumab deruxtecan be continued during radiation?

The patient has extensive disease, and requires palliative radiation to the scapular area (proximal to the brachial plexus) in a region overlapping with a prior palliative course.

Is trastuzumab deruxtecan (T-Dxd) contraindicated during palliative radiation to a non-CNS site, or can it be safely continued during radiation to the shoulder area?

Answer from: Radiation Oncologist at Community Practice

Data is limited, with the suggestion of higher necrosis with SRS. For other sites for palliation, I would not say it’s contraindicated, but caution needs to be exercised especially for the risk of increased lung and GI toxicity (because of independent toxicity from the drug and the potential ...

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Radiation Oncologist at Allegheny Health Network
The elimination half-life is ~6 days so I try to d...

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Can trastuzumab deruxtecan be continued during radiation?

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