Iron Homeostasis   

For example, in a patient with ongoing GI bleeding already on monthly IV iron dextran 1000 mg, would you consider dosing more frequently at Q2 or Q3 w...

How would your recommendation change if the patient has H63 homozygous mutation?

Presuming good medication adherence.

Does this hold true when the patient has significant inflammation? 

HFE gene mutations in C282Y and H63D are negative.

What is the ferritin target that you would aim for? What would be your approach for a ferritin >500? When do you order an MRI liver for iron quanti...

Ferritin >2200, TSAT >80%

Hb <11, low iron saturation (<10%), high ferritin (>900), and low reticulocyte hemoglobin equivalent.

How often do you see non transfusion-dependent thalassemia and how do you approach the treatment?

Although TIBC is negative acute phase reactant, would it be a better indicator of iron deficiency (in combination with ferritin)?

What else would you consider in your differential?

Any particular labs or imaging indicated?

Does transplant eligibility make a difference for management?

For a patient with low ferritin, but high TSAT?

For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?