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Topics:
Pediatric Hematology/Oncology • Internal Medicine • Hematology • Pediatric Hematology • Iron Homeostasis
How would you approach microcytosis without anemia with high TSAT and ferritin?
How often do you see non transfusion-dependent thalassemia and how do you approach the treatment?
Answer from: at Community Practice
This is likely thalassemia trait with iron overload. I would look at the smear to confirm, consider hemoglobin electrophoresis. Sometimes HFE mutations are cofactors that can add to the iron overload so I look for those.
If the ferritin is >300, I consider careful phlebotomy to assess mobilized ...
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