General Internal Medicine

Lupus nephritis

Questions discussed in this category

What is your treatment approach when managing patients with relapsing lupus nephritis who previously achieved remission with mycophenolate and steroids?

6 Answers available

How do you approach the management of patients with suspected membranous lupus nephritis who are found to have positive PLA2R antibodies?

1 Answer available

What is your threshold to repeat a kidney biopsy in a patient with a history of lupus nephritis who is on maintenance therapy and develops subtle changes in urinary protein excretion or microscopic hematuria?

3 Answers available

Would you treat a patient aggressively for lupus nephritis if they have persistent proteinuria over 1 gram but cannot get a timely kidney biopsy?

3 Answers available

Do you routinely monitor the QTc when adding voclosporin to hydroxychloroquine in a patient with lupus nephritis?

1 Answer available

In which clinical scenarios is relying on the urine protein-to-creatinine ratio as a measure of proteinuria unreliable, and interpretations should be made looking at urine protein and urine creatinine separately?

1 Answer available

In patients with lupus nephritis on maintenance therapy, is there additional benefit in utilizing 2 grams vs 3 grams of mycophenolate mofetil (MMF) daily?

3 Answers available

How do you approach the management of immunosuppression in patients with lupus nephritis that go on to dialysis?

3 Answers available

What is your approach to bladder cancer surveillance in patients who have received cyclophosphamide?

1 Answer available

How do steroids and/or DMARDs affect biopsy results if a renal biopsy for suspected lupus nephritis is delayed?

1 Answer available

Papers discussed in this category

Arthritis and rheumatism, 2010-01

Incidence and prevention of bladder toxicity from cyclophosphamide in the treatment of rheumatic diseases: a data-driven review.

J. Rheumatol., 2019 Sep 01

Malignancies in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis: A Population-based Cohort Study.

Kidney international, 2009-12

A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritis.

Clinical journal of the American Society of Nephrology : CJASN, 2010-07

Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study.

Journal of the American Society of Nephrology : JASN, 2010-08

Comparison of different measures of urinary protein excretion for prediction of renal events.

Am J Kidney Dis, 2016 Sep 16

Timed Urine Collections for Albumin and Protein: "The King Is Dead, Long Live the King!".

J Rheumatol, 2004 Aug

Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis.

Kidney international, 2019-01

A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis.

Lancet, 2021 May 07

Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

Journal of clinical pharmacology, 2011-08

Mycophenolic acid pharmacokinetics during maintenance immunosuppression in African American and Caucasian renal transplant recipients.

Arthritis Rheumatol, 2021 May 02

Association of Higher Hydroxychloroquine Blood Levels With Reduced Thrombosis Risk in Systemic Lupus Erythematosus.

Arthritis Rheum,

Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus.

Lupus,

Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis.

Arthritis Rheumatol, 2020 Jan 07

Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy.

Transplant Proc,

A prospective analysis of the effects of enteric-coated mycophenolate sodium and mycophenolate mofetil co-medicated with a proton pump inhibitor in kidney transplant recipients at a single institute in China.

Transpl Int, 2014 Aug 22

Do Asian renal transplant patients need another mycophenolate mofetil dose compared with Caucasian or African American patients?

J Clin Med, 2021 Feb 09

Management of Lupus Nephritis.

Lupus Sci Med, 2018

Serum albumin at 1 year predicts long-term renal outcome in lupus nephritis.

Arthritis and rheumatism, 2013-07

Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio.

Arthritis care & research, 2023 Nov 28

Reference Range of Hydroxychloroquine Blood Levels That Can Reduce Odds of Active Lupus and Prevent Flares.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023 Mar 31

The influence of repeated flares in response to therapy and prognosis in lupus nephritis.

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