Internal Medicine

Cardiology

Questions discussed in this category

What genetic testing would you consider for recurrent arterial events (cryptogenic strokes, MI) in patients with limited risk factors?

Family history is notable for CVA and early onset MI in nonsmokers, but no personal or family history of VTE. APLS testing is negative. Previously fou...

1 Answer available

Does the presence of diastolic dysfunction guide subsequent pharmacological, pacing and ablative therapies for atrial fibrillation?

If so, what diastolic parameters do you look at?

1 Answer available

How many days prior to surgery do you recommend stopping SGLT2 inhibitors and when is it safe to resume therapy?

1 Answer available

For patients over 90 years old, is there any foreseeable benefit to undergoing left atrial appendage occlusion over permanent cessation of anticoagulation, particularly for those at high risk for major bleeding?

2 Answers available

How do you counsel patients on wearable heart monitor devices when they ask about specific products and diagnostic accuracy of these devices available on the market?

2 Answers available

For patients with high-risk stress test features with ischemic EKG changes and mild to no symptoms, what would be your threshold to directly admit them for coronary angiography, or pursue outpatient elective coronary angiogram?

1 Answer available

Would you consider adding niacin to the lipid lowering regimen in statin-intolerant patients who cannot afford PCSK9i or bempedoic acid?

Ferrell et al., PMID 38448791

5 Answers available

Is there a specific INR cut-off value that would prompt you to consider administering vitamin K for patients with mechanical valves requiring urgent non-cardiac surgery and if so, what would be your starting dose?

1 Answer available

With the recent trials such as SELECT and STEP-HFpEF demonstrating benefits of GLP1-agonists in terms of CV risk reduction and improved exercise function, have you begun to incorporate this class of medications into routine CV health maintenance for patients with HFpEF and/or pre-existing CAD?

2 Answers available

For which stroke patients, if any, do you recommend implantable loop recorder for long-term cardiac monitoring and why?

It seems clear that longer monitoring yields more AF detected. What is less clear to me is whether all ILR-detected AF is relevant and merits anticoag...

4 Answers available

Do shorter door-to-balloon (D2B) times impact outcomes in STEMI, if it's already less than 90 minutes, and to what degree (i.e., 30 vs 60 minutes would have a more significant impact)?

1 Answer available

Do you recommend adding low-dose Aspirin for primary prevention in patients with Type 2 Diabetes on Eliquis for another indication?

1 Answer available

In patients who are on 3 of the 4 pillars of HF therapy for HFrEF, would you add the 4th pillar if they are no longer in symptomatic HF and LVEF normalizes?

The basis of the question is that HFrEF trials enroll patients who have Class II-IV symptoms. If their LV systolic function recovers and they become a...

4 Answers available

How do you decide between ordering coronary calcium scoring versus coronary CTA in asymptomatic patients with low to moderate risk for CAD?

6 Answers available

How do you manage patients with atrial fibrillation having a thromboembolic infarct despite being on adequate anticoagulation?

Would you recommend left atrial appendage occlusion with or without continuing anticoagulation? In light of Maarse et al., JAMA Neurology 2024.

3 Answers available

Should all kidney transplant patients be started on statin therapy post operatively given their increased risk of CVD?

At what doses do you start? and how do you titrate therapy?

1 Answer available

What factors do you consider for patients on an individual basis when establishing a post-cardiac arrest MAP goal after ROSC is achieved, considering some may benefit from higher MAP goals for optimal cerebral perfusion?

1 Answer available

When would you consider long-term cardiac monitoring to look for atrial fibrillation in patients with mitral stenosis given their baseline elevated risk for atrial fibrillation and thrombosis?

1 Answer available

What is your approach to GDMT uptitration (particularly dosing for ARBs/ARNIs/MRA) if there is further evidence of renal dysfunction, especially in situations with worsening AKI on CKD?

Would a decrease in eGFR by more than 30% prompt you to consider decreasing or discontinuing these medications?

3 Answers available

How do you manage patients with central sleep apnea due to heart failure with reduced ejection fraction?

Are there specific scenarios in which you employ BPAP with a back up rate?

1 Answer available

How do you approach revascularization in patients over 75 years with NSTEMI, given recent evidence from the SENIOR-RITA trial that an invasive strategy does not significantly reduce cardiovascular events compared to a conservative strategy?

Kunadian, et al., PMID 39225274

1 Answer available

What is your approach to weaning dialysis in a patient with AKI on CKD and CHF who now has resolved AKI but a history of recurrent episodes of decompensated heart failure?

1 Answer available

In ischemic stroke patients with low LDL levels (<30-50 mg/dl), would you consider lowering LDL levels to lower values without concern for any side effects?

How would you adjust statin therapy in these patients?

3 Answers available

What is your approach to evaluating a patient with a suspected myocardial contusion?

1 Answer available

What factors would influence your decision to use or avoid heparin bridging in patients with mechanical heart valves resuming anticoagulation after intracerebral hemorrhage?

In light of a publication by Sakusic et al., PMID 39102615 suggests an increased risk of ICH expansion in patients with heparin bridge compared to sta...

1 Answer available

What clinical parameters or CV imaging considerations would prompt you to consider AV nodal ablation for patients with cardiac amyloidosis and symptomatic atrial fibrillation?

1 Answer available

How do the results of the ESPRIT trial, which evaluated the impact of an SBP target of <120 mmHg on preventing major cardiovascular events, influence your blood pressure management goals for hypertensive patients with diabetes or a history of stroke?

ESPRIT Trial

1 Answer available

How do you choose between finerenone and traditional steroidal MRAs for patients with heart failure and mildly reduced or preserved EF, considering recent results showing finerenone's efficacy in reducing heart failure events?

Soloman, et al., PMID 39225278

1 Answer available

What is your approach to secondary stroke prevention in patients with atrial fibrillation and intracranial stenosis (>70%)?

4 Answers available

Are recurrent UTIs a contraindication to SGLT2i use?

4 Answers available

Would you favor stopping low-dose aspirin and continuing OAC alone in a patient with atrial fibrillation and mild coronary artery calcification seen on routine chest imaging?

2 Answers available

What are some potential etiologies to consider for isolated, mildly elevated BNP levels with normal TTE findings in an asymptomatic, elderly patient?

3 Answers available

Should low-intensity statins be favored to minimize the risk of diabetes onset while still offering cardiovascular benefit for patients with prediabetes where a statin is indicated?

Cholesterol Treatment Trialists' (CTT) Collaboration

2 Answers available

How do you approach long-term blood pressure parameters in ischemic stroke patients with severe symptomatic intracranial stenosis?

How do you balance between having a higher long-term blood pressure to prevent flow failure and leading to worsening of stenosis or occlusion from the...

2 Answers available

Do you routinely perform echocardiography in patients with Staphylococcus aureus bacteremia deemed low risk for metastatic infection, or do you selectively omit it based on specific clinical criteria?

Hendriks, et al., PMID 38576380

2 Answers available

For elderly patients (i.e. older than 80) with only one documented episode of paroxysmal atrial fibrillation following a stress event (such as acute illness/steroid administration) and a CHADsVASc score greater than 1, how would you counsel them on the risks/benefits of anticoagulation and subsequent monitoring for afib recurrence?

1 Answer available

What are first-line choices for vasopressors/inotropes to use in hypotensive patients with Eisenmenger Syndrome?

1 Answer available

When would be your threshold to consider obtaining an exercise RHC for undifferentiated dyspnea to help diagnose HFpEF?

1 Answer available

What is your approach to initiating spironolactone in patients with end stage kidney disease and heart failure?

4 Answers available

What is your preferred, first-line class of anti-anginals for MINOCA with proven epicardial coronary vasospasm?

1 Answer available

How do you approach the management of aortic stenosis in an elderly, frail patient with multiple comorbidities who is symptomatic but considered high risk for surgical aortic valve replacement?

2 Answers available

Can a dihydropyridine calcium channel blocker (CCB) like amlodipine be prescribed in addition to a non-dihydropyridine CCB such as diltiazem or verapamil for treating hypertension?

2 Answers available

Do you routinely check digoxin levels, and if so, when would you consider using Digibind in chronic digoxin use patients?

Is your pattern for drug monitoring different if digoxin is being given for afib vs HFrEF?

3 Answers available

How do you identify the subset of heart failure patients who are likely to benefit from cardiac resynchronization therapy in the setting of an RBBB pattern?

1 Answer available

What patient characteristics prompt you to prescribe vericiguat for patients with heart failure with reduced ejection fraction who are already on standard therapy?

1 Answer available

How is your experience with point-of-care INR systems for home monitoring of vitamin K antagonists?

Are the INRs reliable? In what scenarios would you not recommend POC INR use for warfarin monitoring? Are these typically covered by insurance? Are t...

1 Answer available

How would you manage cardiac sarcoid with intolerance/contraindications to methotrexate, azathioprine, and mycophenolate/mycophenolic acid and that has proven refractory to adalimumab and infliximab as determined by PET?

2 Answers available

Do you favor aspirin or P2Y12 inhibitor monotherapy following completion of 12 months of DAPT post-PCI in patients with elevated bleeding risk?

5 Answers available

What are your management strategies for malignant pericardial effusion with a high risk of spontaneous hemorrhage, particularly in patients requiring anticoagulation for chronic atrial fibrillation?

1 Answer available

Should there be a role for sacubitril-valsartan in the management of patients with heart failure with preserved ejection fraction?

PARAGON HF trial, PMID: 31475794

1 Answer available

Would you recommend starting a moderate-intensity statin in a patient under the age of 40 years old with HIV and a 10-year ASCVD risk estimate below 5%?

The REPRIEVE trial included participants who were between 40 and 75 years old.

1 Answer available

Are there any circumstances in which you would consider PCI for CAV, especially for focal/tubular lesions, if the patient is a candidate for re-transplantation?

2 Answers available

What are your recommendations for the long-term management of patients who have experienced Takotsubo cardiomyopathy, particularly regarding ongoing medication management and follow-up imaging?

1 Answer available

Would you consider opting for beta blocker withdrawal to improve exercise capacity in patients with heart failure with preserved ejection fraction and chronotropic incompetence?

1 Answer available

What is your approach to anticoagulation in patients with hypertrophic cardiomyopathy and an apical aneurysm?

1 Answer available

What is a reasonable approach to coronary calcification that is incidentally found on CT in a patient who does not have symptoms suggestive of angina?

1 Answer available

Should CT coronary calcium score be avoided in dialysis patients in light of presumed high prevalence of CAC in this population?

3 Answers available

How have the findings from DanGer Shock RCT changed your perspective on which patients presenting with acute MI complicated by cardiogenic shock would benefit from Impella for additional hemodynamic support?

2 Answers available

What treatments options may be considered in patients with POTS who also need daily diuretics to treat heart failure and are already wearing compression garments?

3 Answers available

What are your top takeaways from ACC 2024?

3 Answers available

Should we recommend SGLT2i initiation at discharge to all patients hospitalized with acute myocardial infarction?

Butler et al., PMID 38587237

1 Answer available

Is it worth getting a calcium score on a patient who is already on statin therapy?

(Since there is some suggestion that stains convert vulnerable plaque to stable calcified plaque and increase calcium score)

1 Answer available

Is there a role of maximizing GDMT medications for patients with durable VADs?

1 Answer available

How frequently do you obtain lipoprotein (a) levels on asymptomatic patients without a prior history of CAD?

5 Answers available

What is a reasonable class of antihypertensive to start in patients with HCM who remain hypertensive and symptomatic in spite of maximal doses of beta blockade or calcium channel blockers?

1 Answer available

How do you choose between spironolactone and finerenone for patients with proteinuric diabetic kidney disease and heart failure?

2 Answers available

Would you recommend delaying left heart catheterization until development of ESKD in a patient with CKD Stage 5 and stable coronary artery disease given concern for contrast-induced nephropathy?

5 Answers available

How long would you treat a patient with recent history of TAVR presenting with E faecalis bacteremia with unclear source with TEE showing thickened valves but no obvious vegetation?

2 Answers available

Is ABI (Ankle Brachial index) lower limb arterial doppler not recommended if patient already has arterial stents in the legs, and if so, what other imaging modality would you consider as first-line?

1 Answer available

What are alternate approaches to medical therapy and/or interventions to consider in patients with refractory, severe coronary vasospasm despite short-acting nitrates, calcium channel blockers, L-arginine, and clonidine?

5 Answers available

When and for whom should we consider adding bempedoic acid to the lipid lowering regimen?

3 Answers available

Is a daily prophylactic dose of aspirin appropriate for patients with coronary artery calcification by Chest CT or an elevated calcium score?

If so, is there a quantitative calcium score or a reported severity of CT coronary artery calcification that would lead you to start daily aspirin?

6 Answers available

What are your top takeaways from ISHLT 2024?

1 Answer available

Do you recommend taking any unique approaches to managing patients with persistent hypertension following bilateral renal artery stenting?

1 Answer available

What is your approach to counseling a patient with stable but severe multivessel coronary disease if the patient does not wish to undergo bypass surgery?

And when would you consider referral for staged/complex PCI instead?

1 Answer available

If prompted as an outpatient, how do you counsel patients on the rare cardiac complications of vaccinations including myocarditis?

1 Answer available

What is a reasonable way to treat statin-induced myalgia and what statin substitute would you consider using in the event the myalgia is not resolved?

1 Answer available

Can bleeding risk when switching from VKA treatment to a NOAC in frail, elderly patients be accurately compared if individual times in therapeutic range while on VKA treatment are not captured?

Individual times in the therapeutic range while on VKA treatment was not registered in FRAIL-AF.

2 Answers available

What is your target or goal lipoprotein (a) level for patients on PCSK9 inhibitors for either primary or secondary prevention?

2 Answers available

What is the right approach in terms of GDMT and device consideration for patients with intermittent LBBB (QRS duration exceeding 150ms) and HFrEF?

Besides HR variability how can we explain resolution of the intermittent LBBB with HF GDMT (especially with ARNI use)?

1 Answer available

Is there a role for repeat surveillance blood cultures in patients with prosthetic valve endocarditis without associated cardiac abscess after a 6 week course of antibiotic treatment without surgical intervention?

1 Answer available

When would you consider initiating patients with CAD and aortic stenosis on PCSK9 inhibitors (as an adjunct to statin therapy), given favorable findings in the FOURIER trial?

Sabatine et al., PMID 28304224

3 Answers available

Do you recommend bedtime administration of antihypertensives in patients who exhibit nondipping on ambulatory blood pressure monitoring?

3 Answers available

What is the optimal approach to treat isolated diastolic hypertension?

1 Answer available

Do you recommend increasing dietary potassium intake for blood pressure management in non-CKD patients with hypertension?

1 Answer available

When would you consider initiating GDMT for new onset HF in the geriatric population?

1 Answer available

Is there any benefit in maintaining statin or aspirin therapy in patients >75 years old with stable, multivessel ischemic heart disease in light of challenges encountered with polypharmacy?

2 Answers available

In what clinical scenarios do you utilize post-cardiac arrest targeted temperature management (TTM)?

In the span between the HACA trial and the Targeted Temperature Management in Out-of-Hospital Cardiac Arrest study (Dankiewicz et al., PMID 34133859),...

1 Answer available

How do you counsel patients with non-statin associated inflammatory myopathies about statin use?

1 Answer available

How do you manage severe hypertriglyceridemia in the adolescent & young adult population receiving chemotherapy for ALL, in the absence of complications related to hypertriglyceridemia?

1 Answer available

How would you lead a goals of care discussion in terms of prognosis/survival likelihood for patients with inotropic dependent HFrEF with CRT-D on maximally tolerated GDMT?

2 Answers available

What is your approach to diagnosis and evaluation of nonbacterial thrombotic endocarditis (Libman-Sacks)?

Patient with negative blood cultures, completed 6 weeks of IV antibiotics and vegetation persists. CT imaging without evidence of malignancy. No evide...

3 Answers available

How would you manage a patient with CML in chronic phase with a significant cardiac history, such as heart failure with reduced ejection fraction or arrhythmia?

Is there a specific tyrosine kinase inhibitor that you would prefer to use?

1 Answer available

What is your preferred mechanism for venting the left ventricle in patients on VA-ECMO?

2 Answers available

What is a reasonable hemoglobin goal for patients with chronic anemia presenting with acute MI?

1 Answer available

How do you risk stratify patients with different WHO groups of pulmonary hypertension prior to non-cardiac surgeries?

And who would you not recommend to undergo surgeries?

1 Answer available

What would be your second pressor of choice if patients with LVOT obstruction remain persistently hypotensive on phenylephrine?

1 Answer available

How do you decide when to refer patients with obstructive hypertrophic cardiomyopathy for alcohol septal ablation versus septal myectomy?

1 Answer available

Should colchicine be considered in patients with ischemic heart disease and persistently elevated hsCRP despite statin and aspirin therapy and appropriate physical activity?

0 Answers available

Given that there are a fair number of myocarditis cases without a troponin elevation, how do you clinically approach the diagnosis of myocarditis?

1 Answer available

When would you consider using hypertonic saline for patients with refractory acute decompensated heart failure and diuretic resistance?

1 Answer available

What would be your threshold to offer coronary angiography for patients presenting with atypical chest pain features and Wellens syndrome on EKG without a troponin elevation or dynamic EKG changes?

1 Answer available

Can CAR T cell therapy be considered for heart transplant recipients with concurrent lymphoproliferative disorders?

1 Answer available

What is your typical approach to the use of beta blockers in the setting of recent cocaine use amongst patients presenting with cocaine-related MI, arrhythmias, or new-onset heart failure?

If these patients were already prescribed non-selective beta blockers outpatient, do you recommend withholding these medications in the acute phase?&n...

1 Answer available

What is your preferred choice of anticoagulant (VKA vs. DOAC) in patients with an LV thrombus and apical infarct?

Would you extend length of time for anticoagulation if the apex remained akinetic on surveillance TTEs?

2 Answers available

Is there enough evidence now to use injectable semaglutide as a foundational therapy for symptomatic heart failure with preserved ejection fraction in the setting of overweight or obesity?

1 Answer available

Should we begin using bromocriptine for CVD management during pregnancy per ESC guidelines in patients with peripartum cardiomyopathy?

1 Answer available

Do you routinely use vasopressin in the management of RV failure leading to shock state in the absence of an obvious treatable cause such as infarction or PE?

2 Answers available

Which class(es) of antihypertensives do you recommend for first-line therapy for hypertension in severe aortic stenosis?

1 Answer available

Among patients with recovered LVEF on GDMT with a reversible cause for heart failure (i.e., tachycardia-mediated or alcohol-mediated cardiomyopathy), would you consider de-escalation of GDMT?

1 Answer available

Based on results from the VOYAGER PAD trial, when would you consider the primary use of rivaroxaban with aspirin +/- clopidogrel as opposed to conventional aspirin +/- clopidogrel in patients undergoing lower extremity revascularization?

1 Answer available

How reliable is an exercise stress echo in the diagnosis of exercise-induced heart failure with preserved ejection fraction?

Do you have a specific protocol you follow during the stress echo, and if so, what echo parameters are you using to evaluate for exercised-induced hea...

1 Answer available

How do you decide on an outpatient maintenance diuretic regimen for patients approaching discharge for ADHF?

2 Answers available

What is your approach to considering geriatric patients for complex PCI given their overall frailty and increased risk of complications such as bleeding and stroke?

2 Answers available

What is your approach to monitoring patients with cardiac sarcoid while tapering immunosuppression?

Do you obtain serial cardiac PET scans?

1 Answer available

Would you change an elderly, frail patient with atrial fibrillation who is already on a NOAC to VKA treatment?

In FRAIL-AF, switching VKA therapy to a NOAC was associated with higher risk of bleeding in elderly, frail patients.

4 Answers available

What are your outpatient surveillance strategies (biomarkers, imaging, symptoms) to monitor response to treatment for ATTR amyloidosis with cardiac involvement?

How do you determine duration of therapy for Tafamidis, or is it continued indefinitely for the patient?

1 Answer available

What are your top takeaways from AHA 2023?

4 Answers available

When would you consider initiation of low-dose aspirin for primary prevention and/or statin therapy in patients with acceptable bleeding risk and evidence of coronary artery calcification on prior CT chest imaging?

1 Answer available

What is your approach to counseling an octogenarian on the risks and benefits of LHC in the context of NSTEMI complicated by new-onset heart failure and AKI on CKD?

If LHC is deferred, would you consider loading with plavix and treating for ACS for 48 hours (assuming acceptable bleeding risk) and optimizing GDMT p...

1 Answer available

Would you start ASA and/or statin therapy on an asymptomatic patient noted to have incidental pathologic Q waves on EKG, assuming no prior history of ischemic heart disease?

Would you consider further imaging like coronary calcium scoring or coronary CTA to further risk stratify them?

1 Answer available

What other considerations for hyperlipidemia management would you have for a patient with multiple prior PCIs whose LDL remains above goal on high intensity statin, ezetimibe, and evolocumab (assuming compliant with medications)?

2 Answers available

Do you recommend continuing SGLT2 inhibitors in patients with diabetic kidney disease and congestive heart failure who have been taking the medication for several years and later develop end stage kidney disease?

3 Answers available

Do you think that home INR monitoring is a feasible option for elderly, frail patients with atrial fibrillation on VKA treatment, given variations in socioeconomic status and access to care?

2 Answers available

Do you consider bleeding risk in elderly, frail patients with atrial fibrillation to be similar for all NOACs?

In FRAIL-AF, participants were switched from VKA to dabigatran, rivaroxaban, apixaban, and edoxaban.

2 Answers available

When would you consider using acetazolamide to augment diuresis in patients with ADHF?

1 Answer available

Do you usually recommend PFO closure for patients with frequent migraines with aura?

1 Answer available

Do you recommend checking urine sodium 2 hours after loop diuretic administration to determine the need for dose adjustment in a patient with acute decompensated heart failure?

1 Answer available

What is a reasonable surveillance strategy and length of time to maintain patients with thrombosed bioprosthetic valves on systemic anticoagulation?

1 Answer available

What is your approach to a patient who has a cardiac PET scan suggestive of sarcoid but no other supporting evidence of a diagnosis of sarcoid?

Do you typically push for myocardial biopsy in this case?

1 Answer available

How often and when do you consider trending NT-proBNP levels for patients with HFrEF admitted for acute decompensated heart failure?

1 Answer available

How can hepatic venous pressure gradients in patients with cirrhosis be used to differentiate between cardiac cirrhosis and portopulmonary hypertension?

In which clinical scenario(s) would you consider checking HVPG?

3 Answers available

What is your approach to volume resuscitation in patients with obvious septic shock but also with a component of suspected cardiogenic shock?

4 Answers available

Should we routinely include geriatric functional assessments to determine candidacy for TAVR?

(ie., assessing gait speed, cognition, physical function, fall history, orthostatic vital signs, etc.)

1 Answer available

Can Droxidopa be used for augmenting orthostatic hypotension treatment in patients who are already on midodrine and/or fludrocortisone?

Is there an approach to tapering the other two medications while uptitrating Droxidopa dosing to reduce the risk of supine hypertension?

1 Answer available

What is a reasonable blood pressure goal for refractory HTN in the geriatric population?

1 Answer available

Do you recommend noninvasive testing or coronary angiography as the initial test for pre-kidney transplant evaluation of an asymptomatic patient older than 50 years of age with ESKD secondary to diabetic nephropathy and no known history of CAD?

1 Answer available

Should all pregnant patients with newly reduced LVEF <45% be referred as soon as possible to advanced heart failure given high risk for maternal morbidity/mortality in setting of suspected peripartum cardiomyopathy?

If PPCM is suspected, what are your targeted hemodynamic goals during the delivery phase?

1 Answer available

When would you consider initiation of bempedoic acid for statin intolerant patients (i.e. LDL threshold, comorbidities)?

How would you assess response to bempedoic acid and its safety on outpatient labs, and how frequently would you have labs monitored?

1 Answer available

Would you consider adding an SGLT2 inhibitor to augment diuresis in patients with worsening renal function presenting with acute decompensated heart failure and AKI on CKD?

1 Answer available

Is it reasonable to consider the use of DOACs for LV thrombus management instead of coumadin?

3 Answers available

When should cardiac MRI be obtained alongside standard echocardiography for outpatient monitoring of the progression of chronic aortic regurgitation?

How often should cardiac MRI be ordered in this context?

1 Answer available

For which patients do you prioritize ambulatory blood pressure monitoring over self-measured blood pressure?

1 Answer available

What strategies do you employ to minimize the risk of cardiovascular collapse when intubating a patient with severe pulmonary hypertension?

Do you favor awake intubation in these cases?

2 Answers available

Can DOACs be a reasonable alternative (instead of VKA) for management of LV thrombus post-MI and what is a reasonable follow-up time for surveillance outpatient imaging and subsequent duration of therapy outpatient?

1 Answer available

What are the preferred inotropes/vasopressors agents for cardiogenic shock in situations with and without LVOT obstruction?

Is there literature to support superiority of levophed over dobutamine, or vice versa?

1 Answer available

Should a toe-brachial index be obtained in lieu of resting ABI as an initial screen for PAD in high-risk patients such as those with longstanding diabetes or advanced age with stiffened vessels?

1 Answer available

What is your preferred PO afterload-reducing agent immediately after being weaned off inotropic support in cardiogenic shock?

1 Answer available

Would testing for ATTR cardiac amyloidosis be considered in an older patient with bilateral carpal tunnel surgeries and multiple spinal stenosis surgeries, but no obvious cardiac symptoms?

1 Answer available

Do you ever utilize lacosimide in patients with atrial fibrillation?

1 Answer available

Would you recommend giving N-acetylcysteine in addition to holding diuretics in a patient with chronic kidney disease and mild hypervolemia who is planned to have a contrast study?

1 Answer available

What would be your index of suspicion for AL amyloidosis with cardiac involvement in a patient with MGUS to prompt further imaging (and which modality would be preferred)?

1 Answer available

Which clinical and echocardiographic parameters (i.e. LVEF, AVA) do you use when determining patient candidacy for LV device-assisted percutaneous balloon aortic valvuloplasty in patients with cardiogenic shock and severe AS?

1 Answer available

What are your diagnostic and management approaches beyond statin therapy for hyperlipidemia in young adults with significantly elevated LDL levels in isolation (i.e. reasonable calcium score, normal lipoprotein A levels)?

1 Answer available

What would be a reasonable means of mechanical circulatory support as a bridge to AVR for patients with severe aortic regurgitation complicated by cardiogenic shock?

1 Answer available

When should we consider using acarbose for postprandial hypotension?

1 Answer available

Should vasodilatory therapies be considered first-line in the management of hypertension in patients with severe aortic regurgitation?

2 Answers available

Which hemodynamic parameters can be used to titrate positive pressure ventilation in preload dependent settings such as RV failure, cardiac tamponade, HOCM or hemodynamically significant PE?

2 Answers available

How do you approach a patient with atrial fibrillation on apixaban who has a new cardioembolic stroke?

3 Answers available

In patients with Afib on anticoagulation and concurrent intracranial atherosclerotic disease, would you consider adding an anti-platelet to anticoagulation if there are recurrent events that could be related to the ICAD?

1 Answer available

How frequently and when should lipoprotein A levels be monitored?

Are there any significant benefits to lowering moderately elevated lipoprotein A levels?

1 Answer available

Is it sufficient to maintain patients with atrial fibrillation and established PAD on a DOAC or VKA alone, or is there an additional benefit to adding an antiplatelet agent for CVD benefit?

If so, would you prefer a P2Y12i over low-dose aspirin?

1 Answer available

Does the presence and location of cerebral microbleeds affect your decision for antithrombotic treatment in patients with atrial fibrillation?

Do you distinguish between primary and secondary prevention? Wilson et al., PMID 31130428 is helpful, but curious how people apply this data in practi...

3 Answers available

Do you use tolvaptan for management of hyponatremia related to heart failure given the side effect profile and lack of mortality benefit seen in a previous trial?

The EVEREST Outcome trial (Konstam et al., PMID 17384437)

1 Answer available

When you send for molecular studies for polycythemia vera, what are the mutations that predict increased cardiovascular risk?

How do you use this information in clinical practice?

1 Answer available

When would it be reasonable to consider enhanced external counter-pulsation therapy in patients with refractory angina despite maximally tolerated anti-anginal therapy?

4 Answers available

How do you re-stratify patients with a primary prevention ICD in need of a generator change if their LVEF has improved to >40% and they have not previously required any device therapies?

1 Answer available

How do you manage anticoagulation bridging for outpatient ESKD patients given concerns for bleeding risk with enoxaparin in this population?

Would you bridge with enoxaparin 0.7 mg/kg/day in an ESKD patient, as described in a previous retrospective study (Pon et al., PMID: 24718051)?

1 Answer available

Would you recommend PFO closure in patients >60 years old with presumed paradoxical embolism as their mechanism of stroke?

2 Answers available

Should we refer patients with nonischemic cardiomyopathy without a reversible cause for genetic screening, in the absence of any family history of heart failure or sudden cardiac death?

1 Answer available

When is an appropriate time to consider endomyocardial biopsy for non-ischemic cardiomyopathy?

1 Answer available

Should statin initiation be considered in young adult patients with autoimmune disease or chronic inflammatory conditions without an elevated ASCVD risk score given risk of underestimation of underlying CVD?

2 Answers available

Should we routinely incorporate iron studies into admissions for acute decompensated heart failure?

If so, how frequently should we measure iron saturation/ferritin levels post-iron infusion?

1 Answer available

Are there situations where you would start treatment for cardiac amyloid in a patient with amyloid seen on biopsy, but still pending mass spectrometry results?

E.g. in a patient with tenuous cardiac function, would starting treatment several weeks earlier potentially improve outcomes?

1 Answer available

What is your stepwise approach to initiating GDMT in the inpatient setting for newly diagnosed HFrEF?

1 Answer available

For young adults (20-39 years of age) with moderate hypercholesterolemia, should we aim to reduce LDL-C levels by > or equal to 50% and maintain them on long-term statin therapy?

1 Answer available

What is your approach to weaning IABPs?

1 Answer available

For CLL patients with high-risk cytogenetics on ibrutinib who develop a cardiac event such as an MI, would you continue ibrutinib?

Would you continue ibrutinib even if they are placed on anti-platelet therapy such as clopidogrel or ticagrelor? When do you switch to an altern...

5 Answers available

What is your preferred rate control agent for atrial fibrillation with rapid ventricular rate, and why?

1 Answer available

Would you empirically elective to anticoagulate patients with a remote (i.e. >10 year) history of paroxysmal atrial fibrillation presenting with newly diagnosed CVA, presumed cardioembolic in etiology, without any documented recurrence of AF?

3 Answers available

What precautions do you take prior to CABG in a patient with sickle cell trait?

Please comment on temperature recommendations and role of exchange transfusion.

1 Answer available

Would you consider using DOACs in a young patient with SLE and Libman-Sacks endocarditis, who is negative for APS?

2 Answers available

How are PA diastolic goals established and individualized to reduce HF readmission risk post-CardioMEMs, recognizing the overall unclear clinical value of outpatient PA sensor monitoring?

2 Answers available

What is your approach to initiating and titrating midodrine for both inpatient and ambulatory settings?

1 Answer available

What are your preferred ventilatory settings/mode(s) for patients with acute hypoxic respiratory failure presenting with severe biventricular dysfunction in cardiogenic shock?

1 Answer available

Would you favor restarting anticoagulation or pursuing left atrial appendage closure in a patient with hemorrhagic stroke on anticoagulation for non-valvular atrial fibrillation?

3 Answers available

Do you consider the use of bevacizumab in patients with HHT who have high output cardiac failure related to liver AVMs who also have cerebral AVMs?

1 Answer available

When do you start anticoagulation in a patient with cardioembolic CVA secondary to new onset atrial fibrillation with hemorrhagic conversion?

1 Answer available

What are the alternatives to anticoagulation in an individual with an atrial thrombus and absolute contraindications to anticoagulation?

1 Answer available

How does evidence of cerebral amyloid angiopathy/microbleeds affect choices for secondary stroke prevention in patients with a history of ischemic stroke and atrial fibrillation?

How do you approach secondary stroke prevention for patients with ischemic stroke, atrial fibrillation, and signs of cerebral amyloid angiopathy/micro...

1 Answer available

Do you start anticoagulation in a patient with infective endocarditis who also has atrial fibrillation and stroke?

1 Answer available

What are your considerations for peri-operative anticoagulation in patients with a mechanical heart valve undergoing a major noncardiac surgery?

Please comment on bridging.

1 Answer available

For patients with atrial fibrillation on DOAC, when should they resume DOAC after a thalamic bleed without intraventricular bleed?

How does presence of intraventricular hemorrhage change your recommendations?

2 Answers available

How do you counsel patients regarding the cardiovascular risk of febuxostat?

1 Answer available

What is your approach to CLL in patients with atrial fibrillation and/or on anticoagulation?

Do you feel comfortable with BTK inhibitors in these patients? In ELEVATE-RR patients on a/c were excluded, and rate of atrial fibrillation in the ac...

3 Answers available

When do you start anticoagulation for secondary prevention in patients with HFrEF and history of embolic strokes?

For a relatively young, medically compliant patient with HFrEF (EF<35%) and h/o embolic stroke, what is the consensus of starting AC for secondary ...

1 Answer available

When is the best time to consider left atrial appendage closure for secondary stroke prevention in patients with atrial fibrillation?

For example, with a Watchman device? What is the evidence behind this?

1 Answer available

When do you restart anticoagulation in patients with atrial fibrillation who just had an ischemic stroke?

1 Answer available

How do you determine the timing of anticoagulation for patients with large MCA strokes secondary to atrial fibrillation?

1 Answer available

When is it necessary to monitor the QTc interval in patients on hydroxychloroquine?

2 Answers available

What steroid sparing agent do you use for treatment of cardiac sarcoidosis?

Does the type of cardiac involvement impact this choice?

2 Answers available

Do you continue hydroxychloroquine in lupus patients who develop cardiomyopathy?

1 Answer available

How do you manage calcium and vitamin D supplementation in patients with sarcoidosis on chronic steroids?

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2015-12-17

Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia.

Blood, 2022 Jul 14

Long-term outcomes for ibrutinib-rituximab and chemoimmunotherapy in CLL: updated results of the E1912 trial.

Leukemia, 2021 Apr 27

Pooled analysis of safety data from clinical trials evaluating acalabrutinib monotherapy in mature B-cell malignancies.

J Am Coll Cardiol, 2019 Oct 01

Cardiovascular Toxicities Associated With Ibrutinib.

Semin Arthritis Rheum, 2020 Jun

TNF-alpha inhibition for the treatment of cardiac sarcoidosis.

Intern Med, 2014 Dec 01

Treatment with methotrexate and low-dose corticosteroids in sarcoidosis patients with cardiac lesions.

J Am Heart Assoc, 2019 Sep 06

Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.

Clin Rheumatol, 2007 Mar 30

Cardiac sarcoidosis responding to monotherapy with infliximab.

Int J Clin Pract, 2021 Mar 24

Effect of COVID-19 medications on corrected QT interval and induction of torsade de pointes: Results of a multicenter national survey.

Mod Rheumatol, 2021 Feb 09

QTc interval prolongation in patients with systemic lupus erythematosus treated with hydroxychloroquine.

Heart Rhythm, 2020 Jun 28

Effects of hydroxychloroquine treatment on QT interval.

Stroke, 2020 Aug 06

Anticoagulation Type and Early Recurrence in Cardioembolic Stroke: The IAC Study.

Ann Neurol, 2020 Aug 05

Anticoagulation Timing in Cardioembolic Stroke and Recurrent Event Risk.

J Am Coll Cardiol,

Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial.

The New England journal of medicine, 2012-05-17

Warfarin and aspirin in patients with heart failure and sinus rhythm.

The New England journal of medicine, 2018-10-04

Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.

The New England journal of medicine, 2019-05-16

Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.

Heart, 2019 Apr 08

Anticoagulation therapy in heart failure and sinus rhythm: a systematic review and meta-analysis.

American heart journal, 2010-07

Cryptogenic Stroke and underlying Atrial Fibrillation (CRYSTAL AF): design and rationale.

Lancet, 2021 Aug 27

Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial.

The New England journal of medicine, 2018-03-29

Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout.

The New England journal of medicine, 2013-03-21

Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.

Neurology, 2013-08-13

An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke.

The New England journal of medicine, 2017-09-14

Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.

Circ Cardiovasc Interv, 2022 Jun 23

Transcatheter Closure of Patent Foramen Ovale in Older Patients With Cryptogenic Thromboembolic Events.

JAMA, 2021 Dec 14

Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.

JAMA Neurol, 2020 Jul 01

Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke.

JAMA Neurol, 2022 Nov 01

Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure.

Circulation, 2012-09-25

Periprocedural heparin bridging in patients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding and thromboembolic rates.

BMJ, 2021 Jun 09

Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial.

Stroke, 2021 May 24

2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.

JAMA,

Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output.

Ann Intern Med, 2020 Sep 08

Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia.

JAMA neurology, 2019-04-01

Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.

Lancet Neurol, 2019 May 23

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

JAMA Neurol,

Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016.

Lancet Neurol, 2018 Jan 10

The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study.

J Am Coll Cardiol, 2019 Jan 28

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.

Stroke, 2019-06

Perioperative/Postoperative Atrial Fibrillation and Risk of Subsequent Stroke and/or Mortality.

Circulation, 2022 Apr 01

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

JACC Heart Fail, 2022 Dec

How to Initiate and Uptitrate GDMT in Heart Failure: Practical Stepwise Approach to Optimization of GDMT.

Lancet, 2020 Nov 13

Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial.

ESC Heart Fail, 2018 Jan 18

Single-dose intravenous iron in Southeast Asian heart failure patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF).

JAMA, 2022 Feb 01

Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy.

JAMA, 2016-06-28

Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial.

JAMA, 2019-02-12

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial.

Circulation, 2016-11-22

Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association.

JAMA, 2022 Apr 26

Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement.

Journal of the American College of Cardiology, 2023 Nov 21

Long-Term Outcomes of Invasive vs Conservative Strategies for Older Patients With Non-ST-Segment Elevation Acute Coronary Syndromes.

The New England journal of medicine, 2023 Aug 26

Complete or Culprit-Only PCI in Older Patients with Myocardial Infarction.

JACC. Cardiovascular interventions, 2014-07

Futility, benefit, and transcatheter aortic valve replacement.

Struct Heart, 2022 Oct 31

Left Atrial-Veno-Arterial Extracorporeal Membrane Oxygenation: Step-By-Step Procedure and Case Example.

Journal of cardiovascular imaging, 2018 Jun 22

Antihypertensive Treatment in Severe Aortic Stenosis.

European heart journal, 2017 Sep 14

Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study.

European heart journal, 2020 Oct 14

Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry.

Circulation, 2022 Jul 07

Escalating and De-escalating Temporary Mechanical Circulatory Support in Cardiogenic Shock: A Scientific Statement From the American Heart Association.

Journal of the American College of Cardiology, 2018-09-25

Positive Pressure Ventilation in the Cardiac Intensive Care Unit.

J Am Coll Cardiol, 2020 Sep 29

Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk.

Hypertension (Dallas, Tex. : 1979), 2017 Nov 13

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

J Card Fail, 2021 May 26

Captopril Versus Hydralazine-Isosorbide Dinitrate Vasodilator Protocols in Patients With Acute Decompensated Heart Failure Transitioning From Sodium Nitroprusside.

Clinical medicine & research, 2013-12

The role of enhanced external counter pulsation therapy in clinical practice.

Haematologica, 2010-07

Sex differences in the JAK2 V617F allele burden in chronic myeloproliferative disorders.

The American journal of medicine, 1997-01

Inapparent polycythemia vera: an unrecognized diagnosis.

Haematologica, 2019 Aug 14

Masked polycythemia vera: analysis of a single center cohort of 2480 red cell masses.

Journal of the American College of Cardiology, 2014-09-09

Reply: Ejection fraction may improve but the scar still exists! The risk may be lower but not zero.

J Am Coll Cardiol, 2014 Apr 09

Appropriateness of primary prevention implantable cardioverter-defibrillators at the time of generator replacement: are indications still met?

Pediatr Transplant, 2021 Aug

Treatment of post-transplant lymphoproliferative disorder (PTLD) in a heart transplant recipient with chimeric antigen receptor T-cell therapy.

Br J Haematol, 2023 May 2

Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD.

Bone marrow transplantation, 2022 Dec 27

CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review.

Blood advances, 2018-05-22

Epidemiology of AL amyloidosis: a real-world study using US claims data.

JACC CardioOncol, 2020 Mar 17

Plasma Hepatocyte Growth Factor for Diagnosis and Prognosis in Light Chain and Transthyretin Cardiac Amyloidosis.

Mayo Clin Proc, 2010 Aug 16

Prevalence of monoclonal gammopathy of undetermined significance: a systematic review.

ESC Heart Fail, 2021 Dec 08

Echocardiographic and clinical predictors of cardiac amyloidosis: limitations of apical sparing.

The New England journal of medicine, 2002-02-21

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.

N Engl J Med, 2013 Nov 17

Targeted temperature management at 33°C versus 36°C after cardiac arrest.

Cureus, 2022 Sep 11

Targeted Temperature Management After Cardiac Arrest: A Systematic Review.

Crit Care, 2020 Jan 06

High Quality Targeted Temperature Management (TTM) After Cardiac Arrest.

Circulation, 2022 Apr 01

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

N Engl J Med, 2017 Mar 17

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.

JAMA Cardiol,

Off-label Use of Direct Oral Anticoagulants Compared With Warfarin for Left Ventricular Thrombi.

Eur Heart J Cardiovasc Pharmacother, 2022 Sep 29

Apixaban vs. warfarin in patients with left ventricular thrombus: a prospective multicentre randomized clinical trial‡.

Eur Heart J Cardiovasc Pharmacother, 2021 Sep 21

The use of novel oral anticoagulants compared to vitamin K antagonists (warfarin) in patients with left ventricular thrombus after acute myocardial infarction.

ESC Heart Fail, 2020 Jun 25

Direct oral anticoagulants compared to vitamin K antagonist for the management of left ventricular thrombus.

The New England journal of medicine, 2018-02-15

Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine.

Journal of cardiac failure, 2023 Jun 22

Variation in Hemodynamic Assessment and Interpretation: A Call to Standardize the Right Heart Catheterization.

Lancet (London, England), 2015 Jul 15

Small bites versus large bites for closure of abdominal midline incisions (STITCH): a double-blind, multicentre, randomised controlled trial.

The New England journal of medicine, 2020 Mar 30

Initial Invasive or Conservative Strategy for Stable Coronary Disease.

Circulation. Cardiovascular quality and outcomes, 2020 Mar 10

Suboptimal Management of Cardiovascular Risk Factors Among Non-US-Citizen Immigrants: Time to Build a Healthier Immigrant Workforce in the United States.

JAMA cardiology, 2021 Feb 01

Value of Coronary Artery Calcium Scanning in Association With the Net Benefit of Aspirin in Primary Prevention of Atherosclerotic Cardiovascular Disease.

The New England journal of medicine, 2015 Sep 17

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.

The New England journal of medicine, 2020 Sep 24

Dapagliflozin in Patients with Chronic Kidney Disease.

The New England journal of medicine, 2001-08-16

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.

Circulation, 2015 Sep 15

Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.

The Annals of thoracic surgery, 2017 Feb 04

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies.

European heart journal, 2023 Oct 14

2023 ESC Guidelines for the management of endocarditis.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2014-04-18

The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.

Heart rhythm, 2014-07

HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.

Circulation journal : official journal of the Japanese Circulation Society, 2019 Oct 09

JCS 2016 Guideline on Diagnosis and Treatment of Cardiac Sarcoidosis　- Digest Version.

Journal of the American Heart Association, 2024 Jan 19

Impella Versus Intra-Aortic Balloon Pump in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: An Observational Study.

Perfusion, 2021 Jul 28

Veno-arterial extracorporeal membrane oxygenation with concomitant Impella versus concomitant intra-aortic-balloon-pump for cardiogenic shock.

Current problems in cardiology, 2022 Sep 26

Impella Versus Extracorporeal Membranous Oxygenation (ECMO) for Cardiogenic Shock: A Systematic Review and Meta-analysis.

Circulation, 2023 Aug 27

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial.

The New England journal of medicine, 2020 Mar 28

Rivaroxaban in Peripheral Artery Disease after Revascularization.

European heart journal, 2023 Jun 09

Pre-treatment bicarbonate levels and decongestion by acetazolamide: the ADVOR trial.

The New England journal of medicine, 2022 Aug 27

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.

Lupus, 2018 Oct 05

Resolution of large aortic valve vegetations in antiphospholipid syndrome treated with therapeutic anticoagulation: a report of two cases and literature review.

The New England journal of medicine, 2001-11-15

Long-term use of a left ventricular assist device for end-stage heart failure.

International journal of cardiology, 2023 Aug 01

Edge to edge mitral valve repair beyond COAPT criteria: A bridge to further therapies for patients with advanced heart failure.

Lancet (London, England), 2023 Mar 06

Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials.

The New England journal of medicine, 2023 Nov 11

Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia.

Circulation. Heart failure, 2021 Dec 20

Long-Term Survival With Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy.

The New England journal of medicine, 2023 Aug 25

Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.

Circulation, 2023 Nov 13

Sudden Cardiac Death in National Collegiate Athletic Association Athletes: A 20-Year Study.

Circulation, 2023 Nov 11

Arrhythmic Risk In Biventricular Pacing Compared with Left Bundle Branch Area Pacing: Results From The International LBBAP Collaborative Study (I-CLAS).

Circulation. Cardiovascular quality and outcomes, 2023 Nov 06

Off-Label Dosing of Direct Oral Anticoagulants Among Inpatients with Atrial Fibrillation in the United States.

American heart journal, 2017 Apr 24

Rationale and design of the Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial.

The New England journal of medicine, 2023 Nov 11

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.

American heart journal, 2023 Mar 25

Screening for peripartum cardiomyopathies using artificial intelligence in Nigeria (SPEC-AI Nigeria): Clinical trial rationale and design.

JAMA, 2023 Nov 11

Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure: The ARIES-HM3 Randomized Clinical Trial.

Arrhythmia & electrophysiology review, 2020 Dec

Management of Cardiac Sarcoidosis in 2020.

Journal of the American College of Cardiology, 2020 Aug 11

Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel.

Lancet (London, England), 2018 Nov 11

Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial.

JACC. Heart failure, 2020 Feb 05

Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center's Experience.

Medwave, 2015 Aug 27

What are the effects of hypertonic saline plus furosemide in acute heart failure?

Clinical cardiology, 2023 Jun 20

The added value of hypertonic saline solution to furosemide monotherapy in patients with acute decompensated heart failure: A meta-analysis and trial sequential analysis.

American journal of physiology. Renal physiology, 2021 May 10

Induction of renal tumor necrosis factor-α and other autacoids and the beneficial effects of hypertonic saline in acute decompensated heart failure.

The British journal of cardiology, 2022 Jul 19

Age and the power of zero CAC in cardiac risk assessment: overview of the literature and a cautionary case.

Journal of clinical lipidology, 2020 Jan 02

Coronary artery disease with normal lipids and low coronary artery calcium in two women with high lipoprotein(a).

Circulation, 2023 Mar 16

Evaluation and Management of Pulmonary Hypertension in Noncardiac Surgery: A Scientific Statement From the American Heart Association.

Journal of the American College of Cardiology, 2022 May 03

Survival Following Alcohol Septal Ablation or Septal Myectomy for Patients With Obstructive Hypertrophic Cardiomyopathy.

Clinical cardiology, 2020 Feb 19

Beta-blockers withdrawal in patients with heart failure with preserved ejection fraction and chronotropic incompetence: Effect on functional capacity rationale and study design of a prospective, randomized, controlled trial (The Preserve-HR trial).

PloS one, 2023 Nov 16

Effects of beta-blocker withdrawal in patients with heart failure with preserved ejection fraction: A protocol for systematic review and meta-analysis.

Journal of the American College of Cardiology, 2023 Jan 31

Infective Endocarditis After Transcatheter Aortic Valve Replacement: JACC State-of-the-Art Review.

JACC. Cardiovascular interventions, 2022 Jun 13

Long-Term Follow-Up of Hypoattenuated Leaflet Thickening After Transcatheter Aortic Valve Replacement.

JACC. Cardiovascular imaging, 2017 Aug 16

Diagnosis of Infective Endocarditis After TAVR: Value of a Multimodality Imaging Approach.

The New England journal of medicine, 2018 Aug 28

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Sep 11

Real-World Application of Oral Therapy for Infective Endocarditis: A Multicenter, Retrospective, Cohort Study.

Curr Rheumatol Rep, 2020 Aug 26

Lipid-lowering Therapies in Myositis.

The European respiratory journal, 2023 Feb 09

Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017 Nov 15

Distinct Patterns of Hyperpnea During Cheyne-Stokes Respiration: Implication for Cardiac Function in Patients With Heart Failure.

American heart journal, 2020 Oct 13

Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction.

The New England journal of medicine, 2024 Apr 07

Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock.

Circulation, 2016-12-13

Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I).

American heart journal, 2022 May 17

Empagliflozin in patients post myocardial infarction rationale and design of the EMPACT-MI trial.

The New England journal of medicine, 2024 Apr 06

Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes.

Transplantation, 2024 Mar 28

Comparing Plasma Donor-derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study.

Transplant international : official journal of the European Society for Organ Transplantation, 2023 Oct 30

Absolute Quantification of Donor-Derived Cell-Free DNA in Pediatric and Adult Patients After Heart Transplantation: A Prospective Study.

The New England journal of medicine, 2024 Apr 06

Empagliflozin after Acute Myocardial Infarction.

The New England journal of medicine, 2019 Sep 01

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.

JACC. Heart failure, 2020 Mar 30

Effects of Sacubitril/Valsartan on N-Terminal Pro-B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction.

Circulation, 2021 Nov 15

Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial.

The New England journal of medicine, 2022 Aug 27

Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.

The American journal of cardiology, 2004-02-01

Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study).

Nature medicine, 2024 Feb 19

A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.

Journal of clinical lipidology, 2024 Mar 29

A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice.

Circulation, 2019 Nov 17

The Evolving Landscape of Impella Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention With Mechanical Circulatory Support.

JACC. Heart failure, 2020 Nov

Complete Hemodynamic Profiling With Pulmonary Artery Catheters in Cardiogenic Shock Is Associated With Lower In-Hospital Mortality.

The New England journal of medicine, 2013-09-05

Door-to-balloon time and mortality among patients undergoing primary PCI.

Journal of the American College of Cardiology, 2010-02-16

Pre-morbid psychiatric and cardiovascular diseases in apical ballooning syndrome (tako-tsubo/stress-induced cardiomyopathy): potential pre-disposing factors?

Circulation journal : official journal of the Japanese Circulation Society, 2014

Diagnosis of Takotsubo cardiomyopathy.

The New England journal of medicine, 2015-09-03

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.

European heart journal, 2018-06-07

International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management.

European journal of heart failure, 2015 Nov 09

Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology.

ESC heart failure, 2024 Mar 07

Effects of pharmacological interventions on mortality in patients with Takotsubo syndrome: a report from the SWEDEHEART registry.

Journal of clinical medicine, 2021 Aug 02

Takotsubo Cardiomyopathy: Current Treatment.

International journal of cardiology. Heart & vasculature, 2021 Apr 29

Non-steroidal treatment of cardiac sarcoidosis: A systematic review.

The New England journal of medicine, 2010 Sep 22

Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery.

JACC. Cardiovascular interventions, 2020 Feb 12

Balloon Aortic Valvuloplasty as a Bridge to Aortic Valve Replacement: A Contemporary Nationwide Perspective.

Journal of the American College of Cardiology, 2013-01-29

Rehospitalization for heart failure: problems and perspectives.

European journal of heart failure, 2019 Dec 09

Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial.

The New England journal of medicine, 2020 Mar 28

Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction.

Kidney international, 2019-04

Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial.

Kidney360, 2023 Feb 10

Effects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial.

Frontiers in medicine, 2022 Mar 17

Safety and Efficacy of Spironolactone in Dialysis-Dependent Patients: Meta-Analysis of Randomized Controlled Trials.

The international journal of cardiovascular imaging, 2021 Feb 05

The effect of spironolactone on diastolic function in haemodialysis patients.

Circulation. Heart failure, 2010-09

Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction.

Circulation, 2010-08-10

Toward efficient improvements in resuscitation for cardiac arrest.

European heart journal, 2016 May 20

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.

JACC. Heart failure, 2018 May 23

Hemodynamic Correlates and Diagnostic Role of Cardiopulmonary Exercise Testing in Heart Failure With Preserved Ejection Fraction.

Journal of chromatography. A, 2013 Aug 01

Analysis of lignocellulose derived phenolic monomers by headspace solid-phase microextraction and gas chromatography.

The New England journal of medicine, 2024 Sep 01

Invasive Treatment Strategy for Older Patients with Myocardial Infarction.

Stroke, 2007-12

Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

The New England journal of medicine, 2006 Aug 10

High-dose atorvastatin after stroke or transient ischemic attack.

European heart journal, 2020 Jan 01

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.

Journal of the American Heart Association, 2023 Sep 08

Statin Treatment in Patients With Stroke With Low-Density Lipoprotein Cholesterol Levels Below 70 mg/dL.

Lancet (London, England), 2024 Jun 27

Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial.

Neurology, 2024 Aug 05

Timing of Anticoagulation Resumption and Risk of Ischemic and Hemorrhagic Complications in Patients With ICH and Mechanical Heart Valves.

Neurology, 2024 Aug 05

Are Prospective Studies Too Challenging to Execute for Timing of Resuming Anticoagulation After ICH in Patients With Mechanical Heart Valves?

Circulation research, 2020 Jun 18

Population-Based Screening for Atrial Fibrillation.

Journal of the American College of Cardiology, 2024 Aug 29

Effect of Screening for Undiagnosed Atrial Fibrillation on Stroke Prevention.

Circulation, 2019-06-18

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

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