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Internal Medicine

Endocrinology   

Questions discussed in this category

Would elevated bone mineral density/T-score be enough to make a diagnosis of osteopetrosis?
1 Answer available
Does the presence of osteoporosis change the extent of workup that should be performed for an older patient with otherwise serologically low-risk MGUS?
Would your considerations change for a man vs a woman?
1 Answer available
Should we recommend SGLT2i initiation at discharge to all patients hospitalized with acute myocardial infarction?
Butler et al., PMID 38587237
1 Answer available
How many days prior to surgery do you recommend stopping SGLT2 inhibitors and when is it safe to resume therapy?
1 Answer available
Would you recommend RAI ablation therapy to patients with PTC who are s/p hemi-thyroidectomy and decline completion thyroidectomy despite meeting criteria based on pathology results?
1 Answer available
What is the likelihood of recovery of parathyroid gland function for patients who underwent total thyroidectomy, found to have embedded parathyroid glands intra-operatively and then subsequently had them re-implanted into neck muscle?
1 Answer available
When do you recommend plasmapheresis/plasma exchange for management of severe hypertriglyceridemia?
2 Answers available
Would you order a repeat DEXA scan 1 year later for a kidney transplant patient who had an initial DEXA scan within the first 6 months post-transplant showing osteopenia but no history of fractures, and who has been stable on glucocorticoid-free immunosuppressive therapy?
2 Answers available
What factors would lead you to extend the duration of antithyroid drug therapy in a patient with Graves' disease who is clinically euthyroid at 12 months but has risk factors for recurrence?
2 Answers available
Would you recommend waiting for a low Vitamin D level to correct to goal prior to giving a scheduled Prolia injection when transitioning a patient from Zolendronic acid to Prolia therapy for worsening osteoporosis?
2 Answers available
Is there a role for levothyroxine in managing the symptoms of a patient with euthyroid Hashimoto’s thyroiditis?
3 Answers available
Do you interpret failure to develop hypernatremia with prolonged water deprivation (such as for 12 hours) as evidence against diabetes insipidus even if the urine osmolality is just below normal?
For a patient whose sodium remains 142 despite water deprivation from 8 pm to 8 am, with urine osm of about 500, is further testing needed?
2 Answers available
Is there a role for use of GLP1 R agonist or dual agonist therapy for management of post bariatric hypoglycemia and dumping syndrome?
1 Answer available
How do you determine osteoporosis treatment response when patients have discrepant DEXA scan results during monitoring (eg improved BMD of the hip and spine but worsening BMD of the femoral neck)?
1 Answer available
How do you approach managing patients with diabetic kidney disease and proteinuria who develop hypoglycemia after initiation of a SGLT2 inhibitor?
1 Answer available
Do oral contraceptives lower bone mineral density in women with hypothalamic amenorrhea by lowering IGF-1?
1 Answer available
What treatment options would you consider for a young patient with limited mobility, low bone mass and multiple vertebral compression fractures who is on dialysis for advanced kidney disease?
1 Answer available
When and how should we be stopping GLP-1 Receptor Agonist/Dual Agonist therapy?
1 Answer available
Are thyroid molecular tests (such as Afirma, ThyroSeq) validated for use on FNA thyroid nodule samples that are not Bethesda class 3-4?
Clinical scenario where an indeterminate pathology on initial FNA was followed by a “benign” result on a 2nd FNA.
1 Answer available
How do you counsel patients on semaglutide or tirzepatide in light of potential cancer risks?
Do you avoid using these agents only in patients with history of medullary thyroid cancer or pancreatic cancer? Are there other cancer risks we should...
1 Answer available
How do you reduce the risk of contralateral fracture in a patient with atypical femur fracture from prolonged bisphosphonate use?
Do anabolic agents have a role?
1 Answer available
Do you recommend checking both TSI and TBII antibodies for Graves' disease diagnosis and monitoring?
1 Answer available
Do patients with central adrenal insufficiency on maintenance hydrocortisone therapy require doubling of their corticosteroid during chemotherapy cycles?
1 Answer available
Should we be using a cut off of 20 rather than the traditional 10 Hounsfield units to distinguish between benign and malignant adrenocortical tumors on imaging?
Viëtor et al., PMID 34503194
2 Answers available
How frequently do you monitor for hypocalcemia in patients on romosozumab?
1 Answer available
How do you medically manage uncontrolled Graves' disease in a patient awaiting surgery who is intolerant to methimazole and PTU and refusing RAI?
Patient had intolerance to methimazole and then developed agranulocytosis with PTU. FT4 is 2.9 (upper normal range is 1.7). I have started the patient...
1 Answer available
Would you consider adding niacin to the lipid lowering regimen in statin-intolerant patients who cannot afford PCSK9i or bempedoic acid?
Ferrell et al., PMID 38448791
5 Answers available
What workup do you recommend for patients requiring higher-than-expected levothyroxine doses for their weight?
2 Answers available
What is the utility of near-infrared autofluorescence (NIRAF) imaging during parathyroid surgery?
2 Answers available
How often should TSH levels be monitored in patients with a history of Graves' disease who are in remission with negative TSI/TBII antibodies and off medical therapy?
1 Answer available
What clinical sign or symptom do you consider to be the most specific for Cushing syndrome?
1 Answer available
Is there any benefit of using aspirin to mitigate VTE risk in testosterone-induced polycythemia?
2 Answers available
Do you recommend early oral nutrition when managing diabetic ketoacidosis?
Some data showed early enteral nutrition improves outcomes in DKA. Some thought that enteral nutrition could counteract the insulin gtt.
1 Answer available
When do you consider using setmelanotide for treatment of hypothalamic obesity?
2 Answers available
When discontinuing Denosumab after more than 2-3 years of therapy, when do you recommend giving the first dose of zoledronic acid?
2 Answers available
How do you counsel patients with elevated Thyroglobulin Peroxidase antibody levels, diffuse thyroiditis features on ultrasound, non-specific symptoms of fatigue, but normal biochemical thyroid function labs?
1 Answer available
What is the utility of checking reverse T3 in clinical practice?
2 Answers available
Do you recommend adding low-dose Aspirin for primary prevention in patients with Type 2 Diabetes on Eliquis for another indication?
1 Answer available
Can you explain the block and replace approach in the treatment of thyrotoxicosis, including when it is most appropriate to use and how it compares to other treatment options?
1 Answer available
What is the clinical significance of positive anti-thyroid antibodies in a patient that is post-thyroidectomy?
1 Answer available
How do you approach mild prolactin elevations (20-80) in women with galactorrhea on nipple stimulation but regular menses and no plans for pregnancy?
1 Answer available
What strategies do you use to prevent overcorrection of serum sodium in patients with severe hyponatremia and adrenal insufficiency when initiating glucocorticoid therapy?
1 Answer available
Is it necessary to prescribe a steroid taper after two weeks of high-dose prednisone (60 mg daily)?
4 Answers available
Do you recommend non-bypass bariatric surgeries over intestinal bypass procedures for kidney transplant-eligible candidates to prevent oxalate nephropathy, given the higher risk of kidney oxalate deposition with intestinal bypass?
2 Answers available
How do you manage osteoporosis treatment following parathyroidectomy for primary hyperparathyroidism?
1 Answer available
What is the upper limit of blood glucose target in hyperglycemic critically ill patients?
The new SCCM guidelines suggest an upper limit of 200 compared to the conventional 180.
1 Answer available
How should patients time the ingestion of their alendronate and levothyroxine given issues with food/drug interactions?
With the time intervals recommended after taking each medicine, I am wondering how patients should be counseled.
1 Answer available
Should all kidney transplant patients be started on statin therapy post operatively given their increased risk of CVD?
At what doses do you start? and how do you titrate therapy?
1 Answer available
Would you stop denosumab in a patient with chronic kidney disease if they develop asymptomatic hypocalcemia after the injection?
4 Answers available
How soon after radioactive iodine therapy for hyperthyroidism should Methimazole be resumed?
1 Answer available
Would you consider treating empirically for AVP deficiency in a patient who had pituitary surgery 6 months earlier and complaints of polyuria/polydipsia with dilute urine (without performing water deprivation studies)?
2 Answers available
Would you consider PTH analogue in a patient with mildly elevated PTH?
2 Answers available
Does vitamin D supplementation in primary hyperparathyroidism increase the risk of kidney stones?
Is this seen more with high dose vitamin D supplementation?
1 Answer available
Have you been able to safely use other bisphosphonates in patients who developed an allergic reaction (angioedema) to fosamax?
1 Answer available
In ischemic stroke patients with low LDL levels (<30-50 mg/dl), would you consider lowering LDL levels to lower values without concern for any side effects?
How would you adjust statin therapy in these patients?
3 Answers available
What factors guide you in adjusting the dose of fludrocortisone in a patient with primary adrenal insufficiency?
1 Answer available
Is there any evidence that spironolactone or finasteride therapy increase blood levels of testosterone?
2 Answers available
Do you have any specific recommendations to prevent large fluctuations in sodium levels during a colonoscopy prep in patients with central diabetes insipidus on DDAVP?
3 Answers available
Do you recommend the use of bempedoic acid (Nexletol) for treatment of hyperlipidemia in patients with elevated baseline uric acid levels?
Should uric acid levels be monitored regularly while on therapy?
1 Answer available
Which brand/preparation of levothyroxine do you recommend to treat hypothyroid patients with alpha-gal allergy?
If they are already on a preparation that contains animal products, would you change it?
1 Answer available
Would you discontinue romosozumab in a patient who develops a hemorrhagic stroke while on therapy?
5 Answers available
When do you recommend using trabecular bone score (TBS) for managing osteoporosis?
1 Answer available
What work up do you recommend in post bariatric surgery patients who are slowly gaining back the weight despite no changes in diet?
1 Answer available
Would you order a fibroscan to screen for MASLD in patients with insulin resistance but normal LFTs?
1 Answer available
How do you approach the use of GLP-1 receptor agonists for the management of patients with metabolically healthy obesity?
1 Answer available
Aside from adrenal insufficiency and thyroid toxicities, how do you approach other hormonal imbalances during treatment with immune checkpoint inhibitors?
Have you encountered changes in prolactin, testosterone, etc?
1 Answer available
Are recurrent UTIs a contraindication to SGLT2i use?
4 Answers available
Do you recommend parathyroid adenoma resection or ablation for patients with primary hyperparathyroidism and recurrent nephrolithiasis who are found to have a single gland adenoma on parathyroid ultrasound and nuclear medicine imaging?
1 Answer available
Do you recommend the use of GLP1 R agonist therapy in patients with T1DM for weight loss?
3 Answers available
When would you treat mild anemia from low testosterone in an older male?
Would you consider testosterone therapy if he is otherwise asymptomatic?
2 Answers available
What strategies do you employ for adjusting the dosage of levothyroxine in hypothyroid patients who experience significant weight loss or are initiated on GLP-1 receptor agonists?
How often do you recommend monitoring thyroid function tests in these situations?
1 Answer available
For patients with central hypothyroidism and a clear etiology (such as recent head irradiation), do you recommend brain imaging prior to starting thyroid hormone replacement therapy?
2 Answers available
Should low-intensity statins be favored to minimize the risk of diabetes onset while still offering cardiovascular benefit for patients with prediabetes where a statin is indicated?
Cholesterol Treatment Trialists' (CTT) Collaboration
2 Answers available
In your practice, when do you opt to treat unilateral primary hyperaldosteronism medically rather than surgically?
1 Answer available
For patients with metabolic syndrome, is it reasonable to wait for the effect of tirzepatide therapy on their lipid profile prior to starting statin therapy?
4 Answers available
When do you recommend the use of oral testosterone replacement over injectable testosterone?
Ahmad et al., PMID 36106278
1 Answer available
How do you manage antipsychotic-induced prolactinemia?
1 Answer available
What is the optimal anti androgen dose of spironolactone when treating female hirsutism?
1 Answer available
Are there any concerns with live vaccine innoculation and patients who are on denosumab?
1 Answer available
How long does it take the hypothalamic-pituitary-gonadal axis to recover from secondary amenorrhea in the setting early onset and chronic use of oral combined contraceptive pills?
1 Answer available
Is adequate BP control sufficient enough when titrating spironolactone therapy for primary hyperaldosteronism treatment?
2 Answers available
Do progesterone only oral contraceptive pills affect cortisol binding globulin?
1 Answer available
For hypothyroid patients on dual replacement therapy (levothyroxine & liothyronine), do you recommend monitoring TSH while holding off on the morning T3 dose?
3 Answers available
What 60 minute cortisol threshold value do you use for diagnosis of adrenal insufficiency after ACTH stimulation?
Zha et al., PMID 35487459
5 Answers available
What is your approach to management of hyperlipidemia in patients taking JAK inhibitors?
1 Answer available
How do you counsel patients on the use of compounded weight loss medications?
3 Answers available
What factors aside from progression do you consider most important in determining whether a patient with metastatic papillary thyroid carcinoma is radioactive iodine refractory?
What is your evaluation approach for RAI response?  What cumulative dose do you use in practice for deciding a patient is RAI refractory?
1 Answer available
Which fracture sites outside of the classical spine and hip are considered to be osteoporotic fractures even in the absence of a bone density diagnosis?
2 Answers available
How does contralateral suppression of more than 50% with cosyntropin during adrenal venous sampling influence your decision to recommend adrenalectomy in patients with primary aldosteronism?
Okubo et al., PMID 38442744
1 Answer available
Would you recommend changing a patient from the pill form of levothyroxine to Tirosint-SOL if they are started on a proton pump inhibitor?
Yue et al., PMID 38554774
1 Answer available
Do you use absolute random cortisol levels or delta cortisol levels after ACTH stimulation to diagnose adrenal insufficiency in the critically ill?
2 Answers available
What work up do you recommend for persistent subclinical hyperthyroidism with decreased RAI uptake and negative thyroid antibody tests?
1 Answer available
How do you approach a patient with elevated bone specific ALP (>2X the normal limit), but no other evidence of Paget's disease?
Normal Vitamin D, bone scan showed osteoarthritis
1 Answer available
Do you recommend the use of GLP 1 R agonist therapy for obese women with PCOS who are actively trying to conceive?
Dao et al., PMID 38663923
2 Answers available
Do you recommend a particular antiresorptive/anabolic agent for patients who are at high risk for fractures but have high risk of osteonecrosis of the jaw?
3 Answers available
Would you recommend cinacalcet for patients with recurrent nephrolithiasis who have hypercalciuria despite thiazide diuretic use and who also have an elevated PTH level without localizing parathyroid adenoma on imaging?
1 Answer available
What is the typical timeline for remission of autoimmune hypoglycemia?
1 Answer available
What evaluation do you do in patients with hypertension and persistently elevated aldosterone/renin ratio (over 20) but without an elevated aldosterone level (under 10 ng/dL)?
1 Answer available
Is Metformin contraindicated in patients using long term oxygen therapy at home?
Liang et al., PMID 35900801
1 Answer available
How do you adjust your management strategy to address the unique needs of anuric end-stage kidney disease patients when treating diabetic ketoacidosis?
1 Answer available
What are the indications for use of inclisiran over anti-PCSK9 monoclonal antibody therapies?
2 Answers available
Is a history of provoked DVT a contraindication to starting testosterone replacement therapy in a middle aged man with symptomatic hypogonadism who is on anti-coagulation?
1 Answer available
How do you choose between antithyroid drugs, RAI, and surgery for hyperthyroidism patients with existing cardiovascular disease, given their varying effects on cardiovascular outcomes?
Chiung-Hui Peng et al., PMID 38436957
3 Answers available
In obese men presenting with gynecomastia, elevated estrogens, and hypogonadism, what clinical factors would push you to obtain testicular and/or adrenal imaging to rule out an estrogen-producing tumor?
Do you base the decision off of the acuity and course of symptoms? The degree of estradiol elevation? Other factors?
1 Answer available
Is there any contraindication for use of Invisalign teeth aligners in patients undergoing treatment for osteoporosis?
Do treatments for osteoporosis have a large enough effect on tooth movement to make Invisalign less effective?
1 Answer available
Do you adjust the dose or the timing of levothyroxine ingestion in patients on anti-acid medications?
2 Answers available
How would you counsel a female to male transgender patient regarding VTE risk with testosterone therapy, who has additional mild-moderate risk factors for thrombosis?
Additional risk factors could be family history of VTE or thrombophilia, such as antithrombin deficiency.
1 Answer available
Would you transition from denosumab to anabolic agents in patients who are in urgent need for extensive dental work?
2 Answers available
Is active smoking a contraindication to starting menopausal hormone therapy (HRT) in a post-menopausal woman with severe vasomotor symptoms and no other cardiovascular risk factors?
1 Answer available
Given the cardioprotective and renoprotective effects of SGLT2 inhibitors, should we consider administering to patients with well controlled type 1 diabetes despite the risk of DKA?
3 Answers available
Do you recommend using anastrazole in men developing gynecomastia while on testosterone replacement treatment for hypogonadism depending on pre-treatment estradiol level?
1 Answer available
Would you continue Forteo treatment past the recommended 2 years if T scores remain low and procollagen (P1NP) is elevated and if so, how would you monitor response?
1 Answer available
Do you recommend stopping a SGLT2i indefinitely if a patient with chronic kidney disease and diabetes develops euglycemic diabetic ketoacidosis?
1 Answer available
Do you recommend parathyroid imaging testing for patients with recurrent nephrolithiasis who are incidentally found to have an elevated PTH but who do not have hypercalciuria, hypercalcemia, hypovitaminosis D, or chronic kidney disease?
2 Answers available
Do you use the homeostatic model assessment (HOMA) to assess for insulin resistance and change your clinical management of patients?
3 Answers available
What is your approach to managing patients with recurrent nephrolithiasis and nephrocalcinosis in the setting of hypoparathyroidism?
1 Answer available
Would you add cholecalciferol or ergocalciferol to calcitriol therapy in patients with post operative hypoparathyroidism who have low 25 OH vitamin D levels?
Can 25 OH vitamin D be converted to activated vitamin D outside of PTH mediated mechanisms in some organs? 
2 Answers available
For a patient with idiopathic hypercalciuria and a history of calcium kidney stones who has not normalized 24-hr urine calcium level on thiazide diuretic, is there evidence for targeting a certain urine calcium level for decreased future risk of nephrolithiasis and osteoporosis?
2 Answers available
Is it safe to continue administering Prolia per schedule for osteoporosis treatment shortly after a patient has undergone extensive spinal surgery?
1 Answer available
When performing adrenal vein sampling, is calculating selectivity index using androstenedione superior to using cortisol alone for determining successful catheterization?
1 Answer available
What is your approach to progressive calvarial hyperostosis found in an elderly adult not caused by Pagets, acromegaly or hypercalcemia?
No evidence for acromegaly or Pagets. 
1 Answer available
Given the risk of hypocalcemia in dialysis dependent patients treated with denosumab, what is the best method of treatment for osteoporosis for these patients, and should we be transitioning to a different agent?
2 Answers available
Should dopamine agonist treatment stop in pregnant patients with recurrent prolactinoma despite prior surgery?
1 Answer available
What specific clinical factors would drive you to recommend surgical intervention for patients with small, nonfunctional pituitary adenomas who exhibit no neurological symptoms?
1 Answer available
When and how do you taper off cabergoline therapy for treatment of microprolactinoma?
1 Answer available
What is your approach to managing patients with new laboratory evidence of hypopituitarism (e.g. very low plasma ACTH level and low morning serum cortisol) and a remote history of trans-sphenoidal surgery for NFPA?
1 Answer available
Should GLP1 R agonists be used as first line glucose lowering agents in patients with ESKD and DM2?
1 Answer available
In patients presenting with classical findings of primary hyperparathyroidism (i.e mild hypercalcemia, high 24hr urine calcium, elevated 1,25 Vit D but normal PTH), can spontaneous normalization of calcium be explained by episodic hypersecretion of PTH?
1 Answer available
Under what circumstances would you test for hypercortisolism in a patient with insulin resistance?
1 Answer available
Do you recommend adjusting the duration of a drug holiday based on the specific bisphosphonate used when treating osteoporosis?
1 Answer available
Does growth hormone (GH) replacement therapy reduce the risk of fractures in patients with GH deficiency?
1 Answer available
Do you routinely use anti-resorptive medications in patients who have osteoporosis and longstanding hypoparathyroidism?
1 Answer available
What are the clinical indications and major limitations of lipoprotein apheresis?
2 Answers available
How reliable is the FRAX score for assessing risk of osteoporotic fractures?
1 Answer available
Is there any role for 25-OH Vitamin D testing in patients older than 75 years old in the general population?
Demay, et al., PMID 38828931
2 Answers available
Does biotin interfere with the measurement of other metabolites of the Vitamin D pathway outside of the 25-hydroxy Vitamin D assay?
1 Answer available
How would you approach a finding of osteoporosis (Z score -4.5) in a recently postpartum patient who had DEXA sent for long-term low-dose glucocorticoid use?
The patient is actively breastfeeding.
1 Answer available
Are you offering GLP-1 agonists to patients with CKD and diabetes mellitus?
4 Answers available
Is there any evidence regarding bone density gains/fracture reduction in the setting of treatment with romosozumab after a two year course of teriparatide?
Many patients are interested in romosozumab for "maximizing bone gain" and preventing future fractures. Some have had anabolic therapy with teriparati...
1 Answer available
What is the utility of an oral calcium loading test to differentiate FHH from secondary hyperparathyroidism due to low calcium intake?
The patient has very low urinary calcium despite calcium supplements, vitamin D used to be low now normal. Continues to have elevated PTH with normal ...
2 Answers available
Should weight loss medications be used in women who are gaining excessive weight during pregnancy?
1 Answer available
What range of musculoskeletal complaints have you seen with romosozumab use?
1 Answer available
What specific markers or symptoms guide your decision to adjust or stop prophylactic calcium supplementation and calcitriol in managing postoperative hypoparathyroidism following thyroidectomy?
1 Answer available
Would you consider exploratory surgery in a young patient with normocalcemic hyperparathyroidism that meets one or more criteria for parathyroidectomy but has no localized pathology on advanced neck imaging?
1 Answer available
In what clinical scenarios should we use the 2-day 2mg DST instead of the 1mg overnight DST for screening of Cushing syndrome?
1 Answer available
Should all thyroid cancer patients have thyroglobulin levels measured pre-operatively?
2 Answers available
Is ABI (Ankle Brachial index) lower limb arterial doppler not recommended if patient already has arterial stents in the legs, and if so, what other imaging modality would you consider as first-line?
1 Answer available
Should serum calcitonin for surveillance of medullary thyroid cancer be done fasting ?
1 Answer available
Is Macrilen (macimorelin Dx) still available in the US for diagnosis of adult growth hormone deficiency (AGHD)?
1 Answer available
When and for whom should we consider adding bempedoic acid to the lipid lowering regimen?
3 Answers available
Do you recommend obtaining a DEXA scan for patients with recurrent nephrolithiasis and hypercalciuria of unknown etiology?
2 Answers available
What is your approach to differentiating primary from secondary hyperparathyroidism in recurrent kidney stone formers who also have chronic kidney disease, an elevated PTH, and hypercalcemia?
1 Answer available
Should patients with non-functional pituitary macroadenomas with persistent, but tolerable, headaches be recommended for surgery?
1 Answer available
Given the new 2022 WHO classification of pituitary tumors, should we be regularly counseling our patients about the risk of malignancy for what we previously referred to as pituitary adenomas but now classified as pituitary neuroendocrine tumors (PitNETs)?
Asa et al., PMID 35291028
1 Answer available
What is your approach to differentiating diabetes insipidus from primary polydipsia in the outpatient setting?
1 Answer available
In patients with hypertension and suspected primary aldosteronism who have undergone negative confirmatory testing, what follow-up and monitoring strategies would you recommend to ensure early detection of potential aldosteronism?
1 Answer available
Do you routinely check a TSH level in patients with recurrent kidney stones who have hypercalciuria of unknown cause?
1 Answer available
Which patient population would benefit most from cellulose and citric acid (Plenity) therapy for weight loss?
1 Answer available
Has your management of severe hyponatremia changed after a recent observational study described higher in-hospital mortality for sodium correction of <6 mEq/L compared to 6-10 mEq/L in the first 24 hours?
Seethapathy et al., NEJM
5 Answers available
What is your approach to managing osteoporosis in patients with end stage kidney disease?
1 Answer available
Does preoperative use of somatostatin receptor ligand improve remission rates after surgery for acromegaly?
1 Answer available
What is your approach to determining recurrent versus RAI-refractory differentiated thyroid cancer in patients presenting with metastatic disease several years after surgery?
1 Answer available
How do you adjust your HbA1c goal for managing diabetes in elderly patients with multiple chronic illnesses but no limitations in performing self-care tasks?
1 Answer available
Would you use romosozumab in a patient with a cardiovascular event more than 2 years prior?
4 Answers available
Would you refer a patient for parathyroidectomy if they have normal calcium levels, mild hyperparathyroidism, and evidence of osteopenia?
2 Answers available
Do you recommend osteoporosis medication in postmenopausal females on anastrozole with very low Vitamin D (4.5)?
After replacing Vitamin D, what will be your first treatment of choice? Labs including ALP and calcium levels are normal. T scores are -3 or above. Th...
1 Answer available
How do you counsel patients with non-statin associated inflammatory myopathies about statin use?
1 Answer available
Is there a role for cinacalcet suppression testing when evaluating patients for suspected primary hyperparathyroidism who also have recurrent calcium containing kidney stone disease?
1 Answer available
When do you check macroprolactin in the evaluation of hyperprolactinemia?
2 Answers available
Following abaloparatide use for osteoporosis treatment, how long do you consolidate with bisphosphonates before considering a drug holiday?
1 Answer available
Do you routinely use 3% sodium chloride and desmopressin to correct hypovolemic hyponatremia in an asymptomatic patient with serum sodium of less than 120 mEq/L?
3 Answers available
Should patients with hypothyroidism hold their morning levothyroxine dose before going to the lab to check free T4/TSH?
There is literature showing small changes in both free T4 and TSH (despite steady state) in the first few hours after ingestion of L-T4. In occasional...
3 Answers available
Is there a role for Vitamin D supplementation in the treatment of Hashimoto’s thyroiditis?
1 Answer available
After completing 12 months romosozumab, what is the next best treatment option for patients with severe osteoporosis, high risk for fracture, and normal kidney function?
1 Answer available
How do you monitor risk of erythrocytosis from testosterone use for female to male transgender patients?
1 Answer available
Would you do active surveillance or completion thyroidectomy in a patient with 1.6 cm tall cell PTC with posterior margin’s indeterminate and 7 mm isoechoic solid nodule on other side?
Patient is a 41F and overall good surgical risk candidate. 
1 Answer available
How do you counsel a patient with hypothyroidism who complains of persistent hypothyroid symptoms despite achieving normal TSH values with levothyroxine?
1 Answer available
Should patients who develop primary hyperparathyroidism after 5 years of Prolia treatment for osteoporosis be referred for parathyroidectomy?
If so, when? Does surgery need to be timed with last dose of Prolia injection?
1 Answer available
How do you distinguish between primary and tertiary hyperparathyroidism in a patient with ESRD?
1 Answer available
Does norethindrone suppress FSH, LH completely?
If not, what can be possible causes for a postmenopausal woman to have FSH, LH < 0.3 with low E2, and being asymptomatic and doing well otherwise? ...
2 Answers available
What is your daily correction goal for those patients being treated for hypernatremia?
2 Answers available
Would you consider anabolic osteoporosis therapy in a young adult male with multiple non-traumatic vertebral compression fractures and low bone density for age (Z-score -2.6)?
A male patient in his 30s with two lumbar compression fractures (non-traumatic) and a Z-score of -2.6 in the spine, Z-score -0.5 in hips. History of 3...
1 Answer available
Would you recommend switching a diabetic CKD patient on oral semaglutide to the subcutaneous form since the benefits in CKD have primarily been reported in studies using subcutaneous GLP-1 receptor agonists?
1 Answer available
How long do you wait before reassessing a 24 hour urine calcium level in patients with recurrent nephrolithiasis, hypercalciuria, and osteoporosis who are initiated on bisphosphonate therapy?
3 Answers available
Under what circumstances would you refer a patient with mild autonomous cortisol secretion without features of Cushing syndrome for adrenalectomy?
1 Answer available
What is the next step in management of a thyroid nodule that was biopsied and classified as Bethesda III, but Afirma genetic testing reveals parathyroid signature?
Patient does not have hypercalcemia. 
2 Answers available
Should Orlistat be considered in the management of hypertriglyceridemia?
1 Answer available
Do patients with an elevated IGF-1 level and features of acromegaly need to have confirmatory growth hormone suppression testing with OGTT?
Can a diagnosis of acromegaly be made with just an elevated IGF-1 level in patients with features of acromegaly?
2 Answers available
Is intermittent fasting effective for weight loss?
3 Answers available
In a patient with low-risk papillary thyroid carcinoma in 1 thyroid lobe s/p hemithyroidectomy, how would a diagnosis of Graves' orbitopathy (euthyroid biochemically) affect your classification and TSH target for thyroid-cancer treatment?
Conflicting data exists on whether Graves' disease would increase the aggressiveness of the concomitant thyroid cancer vs having no effect/correlation...
1 Answer available
Would you treat an isolated elevated total cholesterol in a post-menopausal patient who is otherwise healthy and has no significant CV risk factors?
2 Answers available
How long should T3 be continued in hypothyroid patients who received no symptomatic benefit after starting T3/T4 combination therapy?
2 Answers available
Would you give a second round of therapeutic RAI in a patient with PTC s/p total thyroidectomy and I-131 ablation who is found to have recurrent disease in cervical lymph nodes s/p repeat neck dissection?
What dose of RAI would you consider giving if recommended?
2 Answers available
Do you treat hypercalciuria in post menopausal osteoporosis with normal serum calcium and PTH?
2 Answers available
Aside from lifestyle measures such as calcium intake, vitamin D repletion, and weight-bearing exercises and ruling out all secondary causes, what is the preferred approach to managing osteoporosis in young women with Z score of less than -2.5 and planning to get pregnant soon?
2 Answers available
Should thyroid hormone replacement be initiated in patients with very prolonged critical illness with associated low thyroid hormone levels?
1 Answer available
Is thyrotropin receptor antibody a good biomarker to predict development of thyroid eye disease?
1 Answer available
Should oral combined contraceptives be held prior to overnight dexamethasone suppression test to rule out Cushings?
If so, how long should OCPs be held to reliably trust the dex suppression test results?
2 Answers available
Can combined oral contraceptive use cause falsely elevated 24-hour urine-free cortisol?
2 Answers available
Is there enough evidence now to use injectable semaglutide as a foundational therapy for symptomatic heart failure with preserved ejection fraction in the setting of overweight or obesity?
1 Answer available
In patients with secondary osteoporosis due to primary hyperparathyroidism, should parathyroidectomy be recommended in the setting of recent prior bisphosphonate use?
1 Answer available
How do you approach a patient with biochemical evidence of primary hyperparathyroidism, but normal parathyroid scan?
4 Answers available
Should testosterone replacement be stopped in elderly men who suffered acute stroke even when testosterone levels have been stably in the low-to-mid normal range?
1 Answer available
Would you recommend prescribing testosterone replacement therapy to reduce osteoporosis fracture rates in men with hypogonadism?
1 Answer available
What is your protocol to starting/stopping glucocorticoid replacement in Cushing disease patients after their transsphenoidal resection surgery?
1 Answer available
Have the results of the ancillary study of the VITAL trial, demonstrating that Vitamin D3 supplementation did not reduce the incident rate of fractures in generally healthy midlife and older adults, changed how you prescribe Vitamin D?
PMID 35939577
2 Answers available
How do you manage osteoporosis in patients with anorexia nervosa (who often are young women < 40)?
2 Answers available
Should metformin be used in women with PCOS for weight loss?
1 Answer available
Should patients with mild subclinical hypothyroidism (TSH < 10 mIU/L) be treated with thyroid hormone replacement to improve their lipid profile?
2 Answers available
Is it possible to have undetectable cortisol levels in secondary adrenal insufficiency?
Young, previously healthy male with normal growth presenting with two syncopal episodes. Currently, only symptom is mild fatigue. Labs showed: Cortiso...
2 Answers available
What is your approach to using bisphosphonates in those with severe hypercalcemia and chronic kidney disease?
1 Answer available
How often would you repeat testing in a patient suspected of Cyclic Cushing's?
And is there a preferred diagnostic test? Whenever cyclic hypercortisolemia is suspected, it is advised that evaluation should be repeated for months,...
2 Answers available
Do you recommend continuing SGLT2 inhibitors in patients with diabetic kidney disease and congestive heart failure who have been taking the medication for several years and later develop end stage kidney disease?
3 Answers available
Is it possible for certain individuals with osteoporosis to be a denosumab "non-responder"?
I’ve seen several such patients who have no secondary causes for bone loss, on adequate calcium/vitamin D, and compliant with denosumab who do n...
1 Answer available
Can joint replacement surgery be performed in someone with active Paget’s disease elsewhere?
1 Answer available
What further work-up (if any) should be considered in patients with pituitary microadenoma and stigmata of Cushing's disease but low ACTH and repeatedly normal plasma, urinary, and salivary cortisol levels?
1 Answer available
What is the differential for elevated T3 (with suppressed T4 and normal TSH) in a patient not taking any thyroid hormones?
Female is in her later 40s with surgical oophorectomy taking Sertraline 50 mg daily and prn Trazodone and Lamotrigine. Has some weight loss and fatigu...
1 Answer available
Is there an indication for adrenalectomy in patients with subclinical Cushing syndrome and adrenal nodule?
1 Answer available
Should lipid lowering therapy be started in patients with isolated elevation in lipoprotein (a) and minimal cardiovascular risk?
2 Answers available
Despite low T scores (-2.5 or worse), what is the actual fracture risk in relatively younger patients (early 50s to mid 60s) with low BMD?
Should this patient population be treated differently? At our institution, we have started using EPIC to screen many patients for osteoporosis and ou...
1 Answer available
Would you start osteoporosis treatment in patients with low FRAX scores but have T scores lower than -2.5?
1 Answer available
What is the best treatment of isolated elevated DHEA-S in a woman with clinical androgen excess (without PCOS, neoplasm, etc)?
1 Answer available
For a TSH producing microadenoma, would you recommend surgery vs methimazole if the patient is elderly and the tumor is relatively small?
The female patient is in her late 70s with cardiac disease (likely due to chronic hyperthyroidism that was missed due to non-suppressed TSH). I’...
1 Answer available
Should insulin be started early (prior to optimization of other anti-hyperglycemic medications) in patients with mild-to-moderate diabetes and hypertriglyceridemia refractory to statin and fibrates?
2 Answers available
Should thyroxine hormone be started in women having fertility concerns with high-normal TSH and negative TPO antibody?
2 Answers available
How should very low T scores (worse than -3) be interpreted in very thin patients (BMI < 18)?
1 Answer available
Can subclinical hypothyroidism cause myxedema coma?
Elderly male with primary hypothyroidism, HTN, and progressive worsening cognition over several months. PCP has been increasing LT4 dose as outpatient...
2 Answers available
In adult women with NCCAH, is there a benefit in using supratherapeutic doses of prednisone in addition to clomiphene to improve fertility rates?
1 Answer available
Which medications do you deem necessary to stop prior to measuring plasma renin and plasma aldosterone when evaluating a patient for possible primary aldosteronism?
1 Answer available
Would you give transdermal hormone replacement therapy to a woman with remote history of provoked pulmonary embolism?
Is patch or gel HRT with ASA prophylaxis a reasonable option after counseling? Or do you add a prophylactic DOAC? 
1 Answer available
Should a short trial of androgen therapy be used in patients with primary adrenal insufficiency suffering from persistent fatigue and hypoactive sexual desire despite sufficient glucocorticoid and mineralocorticoid replacement?
1 Answer available
What is the next best anti-hypertensive medication to start after mineralocorticoid receptor antagonists in patients with primary aldosteronism?
1 Answer available
What is your preferred method for confirming the diagnosis of primary aldosteronism in a patient with an elevated plasma aldosterone to renin ratio?
1 Answer available
Is there any indication for obtaining adrenal imaging in patients with MEN2 who have normal plasma or urinary metanephrines?
1 Answer available
Should patients with asymptomatic GH deficiency be treated with GH replacement therapy if they have prior known severe CAD?
1 Answer available
Does caution have to be used in GH replacement therapy in any and all types of cancer history?
1 Answer available
Is a significant rise in cortisol post cosyntropin stimulation sufficient to rule out adrenal insufficiency in patients with low albumin?
1 Answer available
Can osilodrostat be used indefinitely in poor surgical candidates with cushing syndrome from adrenal adenoma?
1 Answer available
Does your goal rate of correction in patients with chronic hypoosmolar hyponatremia differ based on the degree of hypoosmolarity?
4 Answers available
Should a toe-brachial index be obtained in lieu of resting ABI as an initial screen for PAD in high-risk patients such as those with longstanding diabetes or advanced age with stiffened vessels?
1 Answer available
In a young female with severe osteoporosis due to congenital estrogen deficiency, can estrogen be prescribed if genetic testing for congenital disorders reveals a heterozygous Factor V Leiden mutation?
No prior thrombosis; no family history of thrombosis. As per endocrine, the only useful therapy for the osteoporosis is estrogen. 
1 Answer available
Do you recommend stopping Vitamin D supplementation in a patient with hypercalcemia and a low 25(OH)D level?
1 Answer available
In which patients with chronic kidney disease and low 25-OH vitamin D levels do you prefer weekly ergocalciferol to daily cholecalciferol supplementation?
1 Answer available
Do you treat low 25-OH vitamin D levels in those with end stage kidney disease?
1 Answer available
What is your approach to managing hypocalcemia following a parathyroidectomy in patients with end stage kidney disease?
1 Answer available
How do you approach treatment of osteoporosis in patients with CKD who develop a fragility fracture while on denosumab?
1 Answer available
Do you treat secondary erythrocytosis caused by SGLT2 inhibitor?
1 Answer available
What recommendations do you have for a transgender female patient with history of prothrombin gene mutation who is interested in starting gender affirming hormone therapy?
The patient has no personal history of VTE, but has positive family history of VTE.  Any prophylactic anticoagulation options? How would manage...
1 Answer available
For patients with mild CKD, how do you decide between zoledronic acid and denosumab for bone protection in patients with multiple myeloma?
For pts w/ eGFR between 30-60
1 Answer available
How do you counsel male-to-female transgender patients on the VTE risk of hormonal therapy?
1 Answer available
How do you approach prophylaxis against glucocorticoid-induced osteoporosis in patients with end-stage renal disease on dialysis?
1 Answer available
Do you routinely offer a bisphosphonate or denosumab to multiple myeloma patients without skeletal lesions?
Recommendations in guidelines are discordant (ASCO vs NCCN vs UptoDate).
2 Answers available


Papers discussed in this category

JAMA oncology, 2018-02-01
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
BMJ, 2008 May 20
Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis.
Circulation,
Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study.
Cancer,
A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma.
Blood, 2013-10-24
The impact of response on bone-directed therapy in patients with multiple myeloma.
The Lancet. Oncology, 2011-08
Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial.
The Lancet. Oncology, 2018-03
Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study.
The Journal of clinical endocrinology and metabolism, 2022 Jun 16
Critical Illness-induced Corticosteroid Insufficiency: What It Is Not and What It Could Be.
Semin Dial, 2010 May 10
Why dialysis patients need combination therapy with both cholecalciferol and a calcitriol analogs.
The Journal of clinical endocrinology and metabolism, 2016-05
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline.
Clinical journal of the American Society of Nephrology : CJASN, 2019-05-07
Rate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients.
Curr Opin Cell Biol, 1995 Aug
Cell volume regulated transporters of compatible osmolytes.
Post reproductive health, 2022 Dec 27
Hormone replacement therapy in women with history of thrombosis or a thrombophilia.
Journal of the American Heart Association, 2015 Jun 26
Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Mayo Clinic proceedings, 2023 Jun 29
Progression to Insulin Therapy in Patients With Type 2 Diabetes According to Cardiorespiratory Fitness, Body Mass Index, and Statin Therapy.
The Journal of clinical endocrinology and metabolism, 2011 Dec 28
Update in lipid alterations in subclinical hypothyroidism.
The New England journal of medicine, 2022 Apr 21
Calorie Restriction with or without Time-Restricted Eating in Weight Loss.
The lancet. Diabetes & endocrinology, 2019 Aug 22
Combination denosumab and high dose teriparatide for postmenopausal osteoporosis (DATA-HD): a randomised, controlled phase 4 trial.
The New England journal of medicine, 2019 Mar 23
Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.
BMC medicine, 2019-07-10
The TABLET trial: limitations and implications.
JAMA, 2017 Dec 12
Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial.
The lancet. Diabetes & endocrinology, 2022 Mar 14
Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
The New England journal of medicine, 2020 Sep 24
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
The Journal of clinical endocrinology and metabolism, 2010 Jan 15
Fertility in women with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
The New England journal of medicine, 2023 Jun 16
Cardiovascular Safety of Testosterone-Replacement Therapy.
BMC endocrine disorders, 2024 Nov 18
Risk of Hepatocellular Carcinoma with Glucagon-like Peptide-1 receptor agonist treatment in patients: a systematic review and meta-analysis.
International urology and nephrology, 2024 Nov 04
Effect of GLP-1 receptor agonists on prostate cancer risk reduction: a systematic review and meta-analysis.
Cancers, 2024 Sep 22
Risk of Esophageal and Gastric Cancer in Patients with Type 2 Diabetes Receiving Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs): A National Analysis.
The Journal of clinical endocrinology and metabolism, 2005-04
Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine.
European journal of cancer (Oxford, England : 1990), 2012-07
Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.
The New England journal of medicine, 2015 Sep 17
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.
The New England journal of medicine, 2020 Sep 24
Dapagliflozin in Patients with Chronic Kidney Disease.
The American journal of medicine, 2016-05
Diagnosing and Treating the Syndrome of Inappropriate Antidiuretic Hormone Secretion.
Clinical journal of the American Society of Nephrology : CJASN, 2018-07-06
Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia.
Journal of critical care, 2023 May 13
Effects of correction rate for severe hyponatremia in the intensive care unit on patient outcomes.
The Journal of urology, 1992-06
Functional obstructive uropathy: a significant factor in the hyponatremia of psychogenic polydipsia?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2019-02
THE EVALUATION OF INCIDENTALLY DISCOVERED ADRENAL MASSES.
European journal of endocrinology, 2023 Jul 20
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
JBMR plus, 2021 Aug 30
New Insights Into Osteoclast Biology.
World journal of surgery, 2004 Apr 19
Recovery of bone mineral density in 126 patients after surgery for primary hyperparathyroidism.
The New England journal of medicine, 2023 Aug 25
Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.
Kidney international, 2022 Nov
Executive summary of the KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease: an update based on rapidly emerging new evidence.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023 Jan 18
The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease.
Cardiovascular diabetology, 2024 Feb 08
Cardiorenal effectiveness of empagliflozin vs. glucagon-like peptide-1 receptor agonists: final-year results from the EMPRISE study.
The New England journal of medicine, 2024 May 24
Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes.
The lancet. Diabetes & endocrinology, 2021 Oct 20
Consensus on diagnosis and management of Cushing's disease: a guideline update.
Blood advances, 2017 Dec 21
Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study.
Arteriosclerosis, thrombosis, and vascular biology, 2019-07
Cardiovascular Outcomes of Romosozumab and Protective Role of Alendronate.
The New England journal of medicine, 1980-04-17
Combination of potassium iodide and propranolol in preparation of patients with Graves' disease for thyroid surgery.
International journal of endocrinology, 2015 Oct 20
Lithium Carbonate in the Treatment of Graves' Disease with ATD-Induced Hepatic Injury or Leukopenia.
Clinical journal of the American Society of Nephrology : CJASN, 2017-08-07
Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013-04
Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia.
Thyroid : official journal of the American Thyroid Association, 2018 Apr 05
An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.
Nature reviews. Endocrinology, 2022 Jan 18
Primary hypothyroidism and quality of life.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2020 Sep
Adrenal Vein Sampling Without Discontinuation of Mineralocorticoid Receptor Antagonist Therapy.
European journal of endocrinology, 2022 Nov 22
Cardiovascular outcomes and all-cause mortality in primary aldosteronism after adrenalectomy or mineralocorticoid receptor antagonist treatment: a meta-analysis.
Journal of cardiovascular development and disease, 2022 Sep 08
Stroke Risks in Primary Aldosteronism with Different Treatments: A Systematic Review and Meta-Analysis.
Curr Rheumatol Rep, 2020 Aug 26
Lipid-lowering Therapies in Myositis.
JAMA network open, 2024 Mar 04
MACE and Hyperthyroidism Treated With Medication, Radioactive Iodine, or Thyroidectomy.
The lancet. Diabetes & endocrinology, 2019 Feb 28
Primary therapy of Graves' disease and cardiovascular morbidity and mortality: a linked-record cohort study.
BJS open, 2022 Jul 07
Attaining biochemical euthyroidism early after total thyroidectomy in Graves' disease may lower long-term morbidity risk.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2018-10-05
CALCIUM CREATININE CLEARANCE RATIO IS NOT HELPFUL IN DIFFERENTIATING PRIMARY HYPERPARATHYROIDISM FROM FAMILIAL HERPERCALCEMIC HYPOCALCIURIA: A STUDY OF 1000 PATIENTS.
Pituitary, 2022 May 26
The NETting of pituitary adenoma: a gland illusion.
Clinical endocrinology, 2018-01
Diagnostic performance of unenhanced computed tomography and 18 F-fluorodeoxyglucose positron emission tomography in indeterminate adrenal tumours.
N Engl J Med, 2023 Mar 02
Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence.
The New England journal of medicine, 2024 Apr 06
Empagliflozin after Acute Myocardial Infarction.
Joint bone spine, 2021 May 19
Effects of prior osteoporosis treatment on 12-month treatment response of romosozumab in patients with postmenopausal osteoporosis.
Genes, 2022 Oct 17
Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management.
JAMA, 2007-01-24
Risk of subsequent fracture after low-trauma fracture in men and women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017-07
Osteoporosis in Crisis: It's Time to Focus on Fracture.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019 Dec 01
Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition.
JAMA network open, 2022 Oct 03
Association of Multimorbidity and Excess Mortality After Fractures Among Danish Adults.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022 Oct 17
The Economic Burden of Severe Osteoporotic Fractures in the French Healthcare Database: The FRACTOS Study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020 Mar 16
Fracture risk following high-trauma versus low-trauma fracture: a registry-based cohort study.
The American journal of cardiology, 2004-02-01
Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study).
Nature medicine, 2024 Feb 19
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.
Journal of clinical lipidology, 2024 Mar 29
A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice.
BMJ (Clinical research ed.), 2007 Feb 19
Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials.
European journal of endocrinology, 2003 Dec
Resumption of methimazole after 131I therapy of hyperthyroid diseases: effect on thyroid function and volume evaluated by a randomized clinical trial.
Current osteoporosis reports, 2021 Feb 01
Approaches to Fracture Risk Assessment and Prevention.
The Journal of clinical endocrinology and metabolism, 1974 Nov
Serum thyroid hormone and thyrotropin concentrations during thyroxine and triiodothyronine therapy.
The New England journal of medicine, 2013 Sep 12
Gonadal steroids and body composition, strength, and sexual function in men.
Journal of thrombosis and haemostasis : JTH, 2019 Sep 13
Transgender patients and the role of the coagulation clinician.
The Journal of clinical endocrinology and metabolism, 2024 Jan 18
Approach to the Patient: Hormonal Therapy in Transgender Adults With Complex Medical Histories.
Diabetes research and clinical practice, 1994 Jan
Insulin autoimmune syndrome (Hirata disease): clinical features and epidemiology in Japan.
Clinical endocrinology, 2020 Feb 26
Management of Insulin Autoimmune Hypoglycaemia: Single-centre experience from Western India with systematic review of world literature.
Journal of the Endocrine Society, 2022 Dec 02
Perioperative Evaluation and Management of Patients on Glucocorticoids.
Diagnostics (Basel, Switzerland), 2021 Apr 20
Glucocorticoid Withdrawal-An Overview on When and How to Diagnose Adrenal Insufficiency in Clinical Practice.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2024 Mar 28
Proton Pump Inhibitors Do Not Affect the Bioavailability of a Novel Liquid Formulation of Levothyroxine.
Journal of general internal medicine, 2021 Jan 19
Concomitant Use of Levothyroxine and Proton Pump Inhibitors in Patients with Primary Hypothyroidism: a Systematic Review.
Frontiers in pharmacology, 2023 Mar 16
Glucagon-like peptide-1 receptor agonists as add-on therapy to insulin for type 1 diabetes mellitus.
Nutrition & diabetes, 2019 Nov 04
Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors.
Diabetes, obesity & metabolism, 2019 Aug 19
Double diabetes: A distinct high-risk group?
BMC endocrine disorders, 2021 Sep 16
The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study.
Frontiers in endocrinology, 2022 Aug 18
Cortisol values during the standard-dose cosyntropin stimulation test: Personal experience with Elecsys cortisol II assay.
The Journal of clinical endocrinology and metabolism, 2023 Sep 18
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
European journal of endocrinology, 2018 Apr 27
Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
BMJ open, 2024 Apr 24
Use of GLP1 receptor agonists in early pregnancy and reproductive safety: a multicentre, observational, prospective cohort study based on the databases of six Teratology Information Services.
N Engl J Med,
Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis.
Autoimmunity reviews, 2023 Dec 20
Implementation of regulatory guidance for JAK inhibitors use in patients with immune-mediated inflammatory diseases: An international appropriateness study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020 Apr 24
Radioiodine Ablation of Remaining Thyroid Lobe in Patients with Differentiated Thyroid Cancer Treated by Lobectomy: A Systematic Review and Metaanalysis.
Stroke, 2007-12
Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.
The New England journal of medicine, 2006 Aug 10
High-dose atorvastatin after stroke or transient ischemic attack.
European heart journal, 2020 Jan 01
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.
Journal of the American Heart Association, 2023 Sep 08
Statin Treatment in Patients With Stroke With Low-Density Lipoprotein Cholesterol Levels Below 70 mg/dL.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023 Jul 01
Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging.
Diabetes care, 2021 May 05
High Burden of Subclinical and Cardiovascular Disease Risk in Adults With Metabolically Healthy Obesity: The Atherosclerosis Risk in Communities (ARIC) Study.
Clinical endocrinology, 1978 Nov
Endocrine effects of spironolactone in man.
The Journal of steroid biochemistry and molecular biology, 2013 Mar 06
Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer.
The Journal of clinical endocrinology and metabolism, 2007-05
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.
The Journal of clinical endocrinology and metabolism, 1975 Oct
Effect of spironolactone on sex hormones in man.
Clinical endocrinology, 1978 Dec
Increased serum oestrone and oestradiol following spironolactone administration in hypertensive men.
The New England journal of medicine, 1980-02-21
The importance of circulating 1,25-dihydroxyvitamin D in the pathogenesis of hypercalciuria and renal-stone formation in primary hyperparathyroidism.
The New England journal of medicine, 2018 Sep 13
Primary Hyperparathyroidism.
The Journal of clinical endocrinology and metabolism, 2018 May 01
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
The Journal of urology, 2022 Jan 20
Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy.
Haematologica, 2009 Oct 14
Hematocrit and risk of venous thromboembolism in a general population. The Tromso study.
American journal of hematology, 2023 Jul 20
Sodium-glucose co-transporter-2 inhibitor therapy and unmasking of JAK2-mutated myeloproliferative neoplasm: A Mayo Clinic series of nine consecutive cases.
Kidney360, 2022 Aug 25
Bariatric Surgery Decreases Barriers for Kidney Transplant: Are There Other Weight-Loss Options?
Circulation, 2019-06-18
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Thyroid : official journal of the American Thyroid Association, 2020 May 07
The Detection of Anti-Thyroglobulin Antibodies and Differentiated Thyroid Cancer Recurrence.
Journal of thyroid research, 2020 Apr 14
Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer.
Frontiers in endocrinology, 2023 Dec 04
Near-infrared fluorescent imaging for parathyroid identification and/or preservation in surgery for primary hyperparathyroidism.
Diabetes care, 2024 Aug 01
Hyperglycemic Crises in Adults With Diabetes: A Consensus Report.
European journal of endocrinology, 2008 Jan
TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study.

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