Cervical Cancer   

If so, what do you typically prescribe?

What are your volumes and dose/fractionation for external beam boost in lieu of tandem and ovoid or tandem and ring implant?

Would you consider this stage IVA (spread to adjacent organ) or IVB (spread to distant organ)? For instance, would the presence of direct lumbar verte...

Cervical cancer FIGO stage IIIC2. Bloodwork shows elevated ESR and CRP. 

The 4 cm cuff recurrence occurred 3 years after definitive treatment with hysterectomy and vaginal cuff brachytherapy to 21 Gy. The recurrence had a c...

The trial showed an overall survival benefit of 8% at 5 years with induction chemotherapy (80% vs 72%) utilizing at least 5 cycles of carboplatin-pacl...

Consider treatment of stage IVB cervical cancer with systemic therapy and local pelvic radiation therapy as in Perkins et al., PMID 31810653.

Considering this is stage IV disease, do your recommendations for definitive or adjuvant treatment (after surgery) change?

MRI pelvis shows a 3.5 cm primary that appears infiltrative and without clear parametrial extension on MRI. Staging PET negative.  Is there any ...

When would you use 5-fluorouracil instead of, or in addition to, cisplatin during chemoradiation?

When would you use 5-fluorouracil instead of, or in addition to, cisplatin during chemoradiation? When, if ever, would you offer adjuvant hysterectomy...

Do you include pembrolizumab with platinum-taxane + bevacizumab or reserve it as a second line option?

Assuming minimal toxicities except fatigue from long, recurrent infusions.

Do you try to keep Hb> 10 or 12? Or somewhere in between? 

Previously received pelvic EBRT and intracavitary brachytherapy. IORT was administered to the node-positive side wall at the time of exenteration.

Initially treated with definitive chemoRT but recurred with distant mets. Completed 6 cycles carb/tax/bev with minimal toxicity. Excellent performance...

Lung is biopsy proven met cervix, SBRT is planned. 

Patient did not previously receive para-aortic radiation. Considering RT vs RT  + chemo vs chemo alone

Recurrence was 2cm and PET confirmed local. Excision with positive margins. Current plan for salvage whole pelvic RT and vaginal cuff brachytherapy +/...

If confirmed neuroendocrine and PD-L1 pending, how would you treat?

This has been a common practice in the community. Is there a benefit for certain patients?

Would you be more or less likely to use a cisplatin-containing regimen if a patient had previously responded to chemoradiation with concurrent cisplat...

Does the phase II KN-158 provide sufficient evidence to change management?

Should this be done at the time of recurrence or after failure of 1st line therapy for recurrence?