Medical Oncology

Nephrology

Questions discussed in this category

How do you approach treatment for patients with proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) with end-stage renal disease who are considering kidney transplant?

Most patients with PGNMID have no detectable disease in their marrow or blood and urine protein cannot adequately be monitored.

1 Answer available

How do you monitor multiple myeloma in patients receiving dialysis?

Since free light chains are removed by dialysis and SPEP can also be impacted, is there a reliable way to monitor patients with ESRD and MM?

1 Answer available

Is there any way to safely treat patients with mCRPC with 177-Lu PSMA who are on hemodialysis?

2 Answers available

Do you have a higher threshold regarding when to hold bevacizumab for proteinuria in patients who had known baseline proteinuria from diabetic nephropathy?

2 Answers available

Would you recommend initiating a SGLT2i for proteinuria secondary to bevacizumab in a patient who has a sub-optimal response to an ACEi or ARB?

2 Answers available

What is the management strategy for patients who develop AKI and nephrotic range proteinuria secondary to biopsy proven FSGS during immune checkpoint inhibitor therapy?

1 Answer available

Would you offer adjuvant immunotherapy in a patient with high risk RCC with new/worsening post-op renal dysfunction and CrCl<30?

KEYNOTE-564 required CrCl 30 or above. Not having a baseline/stable CrCl may make it difficult to diagnose or treat IO nephritis.

1 Answer available

Would you consider a BRCA carrier patient for kidney transplantation?

5 Answers available

Do you recommend a kidney biopsy for patients who develop acute kidney injury after starting sacituzumab?

1 Answer available

How do you manage patients blood pressures while on anti-angiogenic TKIs?

Do you insist on ambulatory/home blood pressures to rule in/out white coat hypertension? Does your practice have a system to log patients' BPs to supp...

1 Answer available

What are your next steps for managing biopsy-proven interstitial nephritis from checkpoint inhibitors in patients who do not have a response to prednisone?

3 Answers available

Do you recommend preloading with IV magnesium to decrease the risk of cisplatin nephrotoxicity?

3 Answers available

What is your strategy for managing immunosuppression in patients with a kidney transplant who develop metastatic cancer?

3 Answers available

How is monoclonal gammopathy of renal significance (MGRS) different from myeloma kidney?

If there are light chain deposits on the kidney, is that conclusive of MGRS?

1 Answer available

Would you recommend use of ESA for anemia of kidney disease in the setting of metastatic solid tumor malignancy?

1 Answer available

Have you encountered acute kidney injury after starting eltrombopag for aplastic anemia as part of triple immunosuppressive regimen with ATG and cyclosporine?

1 Answer available

How do you manage hyponatremia in patients with renal cell carcinoma on cabozantinib and nivolumab?

2 Answers available

When do you perform a kidney biopsy in a patient with AKI that is thought to be related to an immune checkpoint inhibitor?

Do you wait to monitor response to empiric corticosteroids before pursuing a kidney biopsy?

2 Answers available

Do you recommend retreatment with an immune checkpoint inhibitor in a patient with a history of immune checkpoint inhibitor-related AKI that resolved with holding the immune checkpoint inhibitor and a glucocorticoid taper?

3 Answers available

Would you consider clearing a patient with essential thrombocytosis for a kidney donation?

1 Answer available

How would you manage an incidental catheter-related thrombosis in a functioning dialysis catheter?

- Dialysis catheter used for hemodialysis- RIJ thrombus in dialysis catheter was incidentally found- Patient asymptomatic with no prior history of VTE...

2 Answers available

What is your preferred first line regimen for myeloma with severe renal impairment, either on or off dialysis?

1 Answer available

Would you consider giving ESA for anemia secondary to chronic kidney disease in a patient with follicular lymphoma in remission and on rituximab maintenance?

1 Answer available

Papers discussed in this category

PLoS One, 2021 Apr 08

Effectiveness and safety of rivaroxaban versus warfarin in Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation: A real-world nationwide cohort study.

Am J Kidney Dis, 2019 Aug 05

The Use of Erythropoiesis-Stimulating Agents in Patients With CKD and Cancer: A Clinical Approach.

Transplantation reviews (Orlando, Fla.), 2021 Jun 24

Management of the kidney transplant patient with Cancer: Report from a Multidisciplinary Consensus Conference.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020 Jan 10

Management of Patients with Renal Failure Undergoing Dialysis During I Therapy for Thyroid Cancer.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023 Jun 08

SNMMI Consensus Statement on Patient Selection and Appropriate Use of Lu-PSMA-617 Radionuclide Therapy.

Cancer, 2017-06-01

Immune checkpoint inhibitors in challenging populations.

N Engl J Med,

Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma.

Cancers, 2022 May 17

Mechanism and Management of Checkpoint Inhibitor-Related Toxicities in Genitourinary Cancers.

International journal of urology : official journal of the Japanese Urological Association, 2023 Jun 06

Tolerability of immune checkpoint inhibitor doublet for advanced renal cell carcinoma patients with pre-dialysis chronic kidney disease or end-stage renal disease.

Oncology research, 2018-04-10

Normalization of Elevated Tumor Marker CA27-29 After Bilateral Lung Transplantation in a Patient With Breast Cancer and Idiopathic Pulmonary Fibrosis.

Balkan journal of medical genetics : BJMG, 2023 May 02

Pathogenic/Likely Pathogenic Variant Patients with Breast, Ovarian, and Other Cancers.

Journal for immunotherapy of cancer, 2020 Oct

Immune checkpoint inhibitor associated reactivation of primary membranous nephropathy responsive to rituximab.

Kidney international, 2018-07

Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft.

BMC nephrology, 2019-02-14

Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

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