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Nephrology

Onconephrology   

Questions discussed in this category

How would you approach management and monitoring of AL amyloidosis with isolated renal involvement?
AL amyloid biopsy proven on renal biopsy. Normal SPEP and FLC, bone marrow biopsy with 10-15% plasma cells.
2 Answers available
Do you recommend holding ACE inhibitors, ARBs, and SGLT2 inhibitors for patients with chronic kidney disease and malignancy who are about to start high-dose intravenous methotrexate?
1 Answer available
What is your approach to ESA use in patients with ESKD and active malignancy on treatment?
2 Answers available
Do you prefer monitoring creatinine over cystatin C levels in patients with lymphoma and chronic kidney disease given the potential for cystatin C levels to be increased with certain malignancies?
Hammouda et al., PMID 28282874
1 Answer available
Do you prefer assessing cystatin C or creatinine when monitoring a patient’s eGFR who is receiving chemotherapy for malignancy?
1 Answer available
Do you have a higher threshold regarding when to hold bevacizumab for proteinuria in patients who had known baseline proteinuria from diabetic nephropathy?
2 Answers available
Would you recommend initiating a SGLT2i for proteinuria secondary to bevacizumab in a patient who has a sub-optimal response to an ACEi or ARB?
2 Answers available
What is the management strategy for patients who develop AKI and nephrotic range proteinuria secondary to biopsy proven FSGS during immune checkpoint inhibitor therapy?
1 Answer available
Would you offer adjuvant immunotherapy in a patient with high risk RCC with new/worsening post-op renal dysfunction and CrCl<30?
KEYNOTE-564 required CrCl 30 or above. Not having a baseline/stable CrCl may make it difficult to diagnose or treat IO nephritis. 
1 Answer available
Do you recommend a kidney biopsy for patients who develop acute kidney injury after starting sacituzumab?
1 Answer available
How do you manage patients blood pressures while on anti-angiogenic TKIs?
Do you insist on ambulatory/home blood pressures to rule in/out white coat hypertension? Does your practice have a system to log patients' BPs to supp...
1 Answer available
What are your management strategies for acute kidney injury attributed to pembrolizumab in patients with a kidney biopsy showing predominately acute tubular injury?
2 Answers available
What are your next steps for managing biopsy-proven interstitial nephritis from checkpoint inhibitors in patients who do not have a response to prednisone?
3 Answers available
Do you recommend preloading with IV magnesium to decrease the risk of cisplatin nephrotoxicity?
3 Answers available
What are your top takeaways from ASN 2023?
2 Answers available
Do you consider hyperuricemia as a potential etiology of an anion gap metabolic acidosis in patients with elevated uric acid levels and no other readily explainable causes of acidosis?
1 Answer available
Are there preventative measures that you take in your cancer patients with chronic kidney disease who require periodic iodinated contrast CT studies for monitoring of their malignancy?
2 Answers available
Do you recommend a kidney biopsy in a patient with myelodysplastic syndrome diagnosed two years prior who develops new onset proteinuria?
1 Answer available
What factors should prompt a kidney biopsy to evaluate for monoclonal gammopathy of renal significance in a patient with MGUS and suspected chronic diabetic nephropathy?
1 Answer available
How frequently do you monitor urine protein levels in a patient receiving bevacizumab who develops proteinuria of less than 2 grams per day?
2 Answers available
Do you recommend performing a kidney biopsy in patients with suspected ifosfamide nephrotoxicity?
1 Answer available
Would you recommend initiating RRT in a patient with tumor lysis syndrome and a phosphorus of 9 mg/dl or more who does not have symptomatic hypocalcemia or other indications for dialysis?
1 Answer available
Should CAR-T therapy be considered for a kidney transplant patient with refractory PTLD?
1 Answer available
How do you manage hyponatremia in patients with renal cell carcinoma on cabozantinib and nivolumab?
2 Answers available
When do you perform a kidney biopsy in a patient with AKI that is thought to be related to an immune checkpoint inhibitor?
Do you wait to monitor response to empiric corticosteroids before pursuing a kidney biopsy?
2 Answers available
Do you recommend testing for G6PD deficiency in those with whom rasburicase for tumor lysis syndrome is indicated?
2 Answers available
Do you recommend retreatment with an immune checkpoint inhibitor in a patient with a history of immune checkpoint inhibitor-related AKI that resolved with holding the immune checkpoint inhibitor and a glucocorticoid taper?
3 Answers available


Papers discussed in this category

Kidney international reports, 2021 Jan 06
Spectrum of Kidney Involvement in Patients with Myelodysplastic Syndromes.
Cancer, 2017-06-01
Immune checkpoint inhibitors in challenging populations.
N Engl J Med,
Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma.
Cancers, 2022 May 17
Mechanism and Management of Checkpoint Inhibitor-Related Toxicities in Genitourinary Cancers.
International journal of urology : official journal of the Japanese Urological Association, 2023 Jun 06
Tolerability of immune checkpoint inhibitor doublet for advanced renal cell carcinoma patients with pre-dialysis chronic kidney disease or end-stage renal disease.
Journal for immunotherapy of cancer, 2020 Oct
Immune checkpoint inhibitor associated reactivation of primary membranous nephropathy responsive to rituximab.
Clinical journal of the American Society of Nephrology : CJASN, 2024 Jun 07
Assessment of Glomerular Filtration Rate in Patients with Cancer: A Statement from the American Society of Onco-Nephrology.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2019 Oct 09
The utility of repeat kidney biopsy in systemic immunoglobulin light chain amyloidosis.
N Engl J Med,
Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis.

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