Primary Care

NCI-CCC Tumor Board Question

These are questions being discussed by academics at NCI-Cancer Centers

Questions discussed in this category

In which scenarios do you use vaginal estrogen in patients with history of HR positive breast cancer?

Do you feel differently about using these in patients with a history of HR-negative breast cancer?

When would you feel comfortable with patients who have a history of hormone-receptor positive breast cancer using hormonal IUDs (e.g. Mirena)?

2 Answers available

In terms of contraception, what do you recommend for patients with a history of hormone receptor-negative compared to hormone receptor-positive breast cancer?

1 Answer available

Is there evidence that oral contraceptive pills are less effective in pre-menopausal women on tamoxifen chemoprevention?

We usually recommend copper IUDs, but that's not feasible in all women.

1 Answer available

For patients on a bone-modifying agent for osteoporosis/severe osteopenia in the context of adjuvant AI therapy, how do you manage the bone-modifying agent once their AI course is complete?

1 Answer available

Would you consider HRT after BSO in a pre-menopausal gBRCA2+ patient who has no intention of ever having prophylactic bilateral mastectomies and who declines chemoprophylaxis?

2 Answers available

How do you counsel patients with a curable breast cancer that there is no indication for additional surveillance imaging after treatment other than continuing annual mammograms?

4 Answers available

How do you advise women who are at high risk for breast cancer and for whom annual screening breast MRIs are recommended regarding the long-term risks of gadolinium contrast?

1 Answer available

Would you consider giving tamoxifen prophylaxis to young women with pathogenic BRCA2 muations who are <35 years old?

Tamoxifen prophylaxis has not been studied in women <35 years old, but it would be reasonable to assume they would benefit.

1 Answer available

How do you counsel your breast-cancer survivors about weight-loss/dietary modifications?

Do your recommendations differ if patients are pre or postmenopausal given the data?

3 Answers available

For patients at high risk of breast cancer, do you recommend tomosynthesis over traditional two-view screening mammogram?

1 Answer available

How do you counsel a patient with a history of breast cancer regarding use of breast MRI for screening?

Patient does not qualify for breast cancer screening by annual MRI per criteria (IBIS lifetime risk<20%, no known genetic predisposition,...

1 Answer available

At what point do you prescribe duloxetine for the treatment of AIMS (aromatase inhibitor induced musculoskeletal syndrome)?

2 Answers available

Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-02-01

Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage Breast Cancer: SWOG S1202.

European radiology, 2022 May 07

Background parenchymal enhancement in contrast-enhanced MR imaging suggests systemic effects of intrauterine contraceptive devices.

The Cochrane database of systematic reviews, 2020 Dec 21

Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.

Journal of the National Cancer Institute, 2006-12-20

Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study.

Medicine and science in sports and exercise, 2010-07

American College of Sports Medicine roundtable on exercise guidelines for cancer survivors.

J Clin Oncol, 2016 Feb 20

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.

Curr Breast Cancer Rep, 2016-01-01

Reducing the Risk of Breast Cancer Recurrence: an Evaluation of the Effects and Mechanisms of Diet and Exercise.

Crit Rev Food Sci Nutr, 2018 Apr 19

Meat, eggs, full-fat dairy, and nutritional boogeymen: Does the way in which animals are raised affect health differently in humans?

JAMA, 2018-02-20

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial.

JAMA Oncol,

Prolonged Nightly Fasting and Breast Cancer Prognosis.

Lancet Oncol., 2016 Jun 23

Breast cancer screening with tomosynthesis (3D mammography) with acquired or synthetic 2D mammography compared with 2D mammography alone (STORM-2): a population-based prospective study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-09-01

Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-06-15

Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers.

J. Natl. Cancer Inst.,

Twenty-year follow-up of the Royal Marsden randomized, double-blinded tamoxifen breast cancer prevention trial.

Obstet Gynecol,

Long-term mortality associated with oophorectomy compared with ovarian conservation in the nurses' health study.

JAMA,

Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women's Health Initiative Randomized Clinical Trials.

Cancer Prev Res (Phila), 2019 Aug 16

Effect of Bazedoxifene and Conjugated Estrogen (Duavee) on Breast Cancer Risk Biomarkers in High-Risk Women: A Pilot Study.

J Clin Oncol, 2019 Sep 18

Management of Osteoporosis in Survivors of Adult Cancers With Nonmetastatic Disease: ASCO Clinical Practice Guideline.

JAMA oncology, 2024 Jan 01

Vaginal Estrogen Therapy Use and Survival in Females With Breast Cancer.

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NCI-CCC Tumor Board Question

Questions discussed in this category

Papers discussed in this category

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