Fertility Preservation

Questions discussed in this category

How do you approach fertility preservation in a young child with cancer?

What is the best way to counsel families in regards to their child's risk of infertility and need for fertility preservation?

2 Answers available

Is there a concern for the potential of future congenital malformations in offspring when preservation of eggs and sperm is done AFTER cyclophosphamide treatment given that it is an alkylating agent?

1 Answer available

Do you recommend sperm banking for males prior to undergoing radiation?

Is it necessary to delay the start of radiation therapy for males planning on sperm banking for fertility preservation?

2 Answers available

In which situations do you offer ovarian suppression with chemotherapy to prevent the development of premature menopause in premenopausal women with ER negative breast cancer?

Fertility preservation already complete with embryo cryopreservation

1 Answer available

Do you recommend a waiting period to conceive after prostate radiation?

1 Answer available

When, if ever, would you consider ovarian preservation in a premenopausal patient with high grade endometrial carcinoma?

If the patient was interested in fertility preservation would you recommend oocyte preservation before or after hysterectomy - or not at all?

1 Answer available

Do you offer adjuvant bisphosphonates to high-risk premenopausal women on ovarian suppression for early-stage breast cancer who would want to consider pregnancy in the future?

Which agents would you select and for how long would you treat them?

1 Answer available

How long should patients treated with frontline therapy for Hodgkin lymphoma wait before attempting to conceive a child?

Do your recommendations differ between those who receive ABVD and escalated BEACOPP? Do you recommend consultation with fertility specialists for all...

1 Answer available

Can an AYA patient with newly diagnosed AML safely sperm bank after starting cytoreduction with hydroxyurea or cytarabine?

2 Answers available

Should gonadotropin-releasing hormone (GnRH) agonists be offered to all women of reproductive age about to undergo treatment with cyclophosphamide?

2 Answers available

For pre-menopausal female patients who present with acute leukemia in need of urgent anti-neoplastic therapy, what is your preferred approach in effort to preserve fertility?

Does acute leukemia sub-type affect your decision?

1 Answer available

What adjuvant therapy would you recommend for a Stage IIIC low grade serous ovarian cancer following following fertility sparing surgery?

1 Answer available

Do you offer fertility preservation to patients prior to CAR-T therapy?

Do you limit it to post-pubertal patients? Do you offer it only if they will proceed with bone marrow transplantation after CAR-T?

1 Answer available

How successful is IVF after definitive radiation therapy to the pelvis for endometrial cancer?

How do you counsel a pre-menopausal female with endometrioid cancer desiring definitive RT with egg harvesting and IVF for fertility preservation inst...

2 Answers available

What techniques do you use to address fertility preservation in young female patients being treated with chemoradiation therapy for cancer in the pelvis?

How do you prevent early menopause in women? Please comment on freezing of eggs, oophopexy, supine vs prone position, vaginal dialator.

4 Answers available

Do you use any dose constraints ovaries/uterus in premenopausal women receiving pelvic RT and hoping to preserve fertility?

Do you use a different set of dose constraints for situations requiring treating much of the pelvis, e.g. rectal cancer, versus partial pelvis, e.g. a...

1 Answer available

Do you counsel young patients on infertility risks following HO prophylaxis with RT?

How long do you advise them to refrain from unprotected sex following RT? I was trained to discuss these issues with patients but the gonada...

3 Answers available

For women who have had either embryo or oocyte cryopreservation, do you also recommend administering GnRH analogs?

1 Answer available

Is there a subset of breast cancer patients who may benefit more from GnRH analogs for fertility preservation compared to others?

1 Answer available

How do you approach and counsel women with high risk, early stage breast cancer requiring chemotherapy for whom fertility preservation is a major concern?

2 Answers available

When would you consider treating a testicular relapse with definitive radiation in a child with ALL?

1 Answer available

What are your indications for treating a pelvic desmoid tumor in a young woman concerned with fertility?

1 Answer available

When do you suggest ovarian suppression for fertility preservation in premenopausal women receiving neo/adjuvant chemotherapy?

Do you reserve this approach for only women with triple negative breast cancer or all-comers?

1 Answer available

Would you recommend the SOFT/TEXT adjuvant approach of ovarian suppression/AI in a premenopausal woman with high-risk disease who still desires to have a pregnancy?

1 Answer available

After chemotherapy for early and locally advanced breast cancer, how long do you advise women to wait before attempting to conceive?

Does your recommendation change depending on the agents they received?

1 Answer available

What is the likelihood of a successful pregnancy following pelvic irradiation?

How should we counsel young women who are receiving treatment for GI/GYN malignancies?

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2015-03-05

Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy.

N. Engl. J. Med., 2015-01-29

Adjuvant ovarian suppression in premenopausal breast cancer.

Lancet, 2007-05-19

Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials.

J. Clin. Oncol., 2018-07-01

Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient-Level Data.

Annals of oncology : official journal of the European Society for Medical Oncology, 2013-09

Utility of gonadotropin-releasing hormone agonists for fertility preservation in young breast cancer patients: the benefit remains uncertain.

Oncologist, 2007-09-01

How to preserve fertility in young women exposed to chemotherapy? The role of GnRH agonist cotreatment in addition to cryopreservation of embrya, oocytes, or ovaries.

Cancer, 1994-01-01

Treatment of overt isolated testicular relapse in children on therapy for acute lymphoblastic leukemia. A report from the Childrens Cancer Group.

Med. Pediatr. Oncol.,

Gonadal and sexual function in men treated for childhood cancer.

Arch. Dis. Child.,

Survival and endocrine outcome after testicular relapse in acute lymphoblastic leukaemia.

Pediatric blood & cancer, 2018-05

Isolated late testicular relapse of B-cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response-based testicular radiation: A Children's Oncology Group study.

Br. J. Haematol.,

PCR assessment of bone marrow status in 'isolated' extramedullary relapse of childhood B-precursor acute lymphoblastic leukaemia.

The New England journal of medicine, 2018-07-12

Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.

Fertil. Steril., 2013 Sep 05

Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion.

Radiat Oncol, 2015 Feb 22

Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation.

Obstet Gynecol,

Treatment of clear cell adenocarcinoma in young females.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01

Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum.

Gynecol. Oncol., 2017 Jul 30

Primary cytoreductive surgery and adjuvant hormonal monotherapy in women with advanced low-grade serous ovarian carcinoma: Reducing overtreatment without compromising survival?

Arthritis and rheumatism, 2005-09

Use of a gonadotropin-releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus.

Arthritis & rheumatology (Hoboken, N.J.), 2015-05

Randomized, double-blind, dose-escalation trial of triptorelin for ovary protection in childhood-onset systemic lupus erythematosus.

Lupus,

Preservation of fertility and ovarian function and minimizing gonadotoxicity in young women with systemic lupus erythematosus treated by chemotherapy.

Best Pract Res Clin Obstet Gynaecol, 2019 Nov 13

Ovarian protection with gonadotropin-releasing hormone agonists during cyclophosphamide therapy in systemic lupus erythematosus.

Journal of adolescent and young adult oncology, 2020 May 26

Standardizing Risk Assessment for Treatment-Related Gonadal Insufficiency and Infertility in Childhood Adolescent and Young Adult Cancer: The Pediatric Initiative Network Risk Stratification System.

Clin Transl Oncol, 2020 Sep 17

ABVD and BEACOPP regimens' effects on fertility in young males with Hodgkin lymphoma.

J Assist Reprod Genet, 2020 Jun 02

Impact of ABVD chemotherapy on ovarian reserve after fertility preservation in reproductive-aged women with Hodgkin lymphoma.

Lancet Oncol, 2018 Sep 13

Determinants of ovarian function after response-adapted therapy in patients with advanced Hodgkin's lymphoma (RATHL): a secondary analysis of a randomised phase 3 trial.

Lancet,

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials.

J Clin Oncol, 2022 Jan 18

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update.

International journal of radiation oncology, biology, physics, 2010-06-01

Incidental testicular irradiation from prostate IMRT: it all adds up.

International journal of radiation oncology, biology, physics, 2012-01-01

Testicular doses in image-guided radiotherapy of prostate cancer.

JCO oncology practice, 2023 Feb 10

Fertility Preservation Practices at Pediatric Oncology Institutions in the United States: A Report From the Children's Oncology Group.

Related Topics