Iron Homeostasis   

Presuming good medication adherence.

After what time period would you consider adding a second iron chelator?

Does this hold true when the patient has significant inflammation? 

HFE gene mutations in C282Y and H63D are negative.

How would your recommendation change if the patient has H63 homozygous mutation?

Are there specific safety or efficacy benefits associated with prolonged infusion times in this population?

What is the ferritin target that you would aim for? What would be your approach for a ferritin >500? When do you order an MRI liver for iron quanti...

Ferritin >2200, TSAT >80%

Anemia is secondary to menorrhagia. No gynecologic interventions were possible.

Hb <11, low iron saturation (<10%), high ferritin (>900), and low reticulocyte hemoglobin equivalent.

How often do you see non transfusion-dependent thalassemia and how do you approach the treatment?

Although TIBC is negative acute phase reactant, would it be a better indicator of iron deficiency (in combination with ferritin)?

What else would you consider in your differential?

Any particular labs or imaging indicated?

What is the ideal approach for female adolescent athletes if they have complaints of fatigue and dizziness and are diagnosed with mild iron deficiency...

i.e. similar to CKD anemia?

Patient with ferritin level <1000 ng/mL and no evidence of end-organ damage

e.g. a genetic mutation picked up through a family member

Does transplant eligibility make a difference for management?

For a patient with low ferritin, but high TSAT?

For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?