Palliation

Genitourinary Cancers

Questions discussed in this category

How do you manage hot flashes in men with prostate cancer on androgen deprivation therapy?

16 Answers available

How aggressive would you be in irradiating asymptomatic bone metastases in a patient with metastatic prostate cancer?

Notably, the patient presented with renal failure due to ureteral obstruction and hydronephrosis, receives hemodialysis, and has limited systemic opti...

4 Answers available

Do you recommend prostate RT for patients with metastatic (M1) disease?

A recent NCBD analysis (Rusthoven et al., PMID 27325855) suggests that the addition of prostate RT significantly improves survival compared to AD...

8 Answers available

Is it safe to deliver SBRT to progressive lung metastases to patients with metastatic RCC receiving concurrent pazopanib?

2 Answers available

Would you offer RT to a large infiltrative renal metastasis in a patient with minimal other systemic disease?

What factors would you consider? What if this meant treatment of the full kidney? If treatment is recommended, would you utilize an SBRT approach...

2 Answers available

When should SBRT be offered to oligometastatic bone disease in a patient with prostate cancer?

What factors should be considered with offering SBRT to oligometastatic bone disease in prostate cancer patients? Should this been done off of a proto...

2 Answers available

Papers discussed in this category

Eur Urol, 2015 Jul 16

Progression-free Survival Following Stereotactic Body Radiotherapy for Oligometastatic Prostate Cancer Treatment-naive Recurrence: A Multi-institutional Analysis.

BJU Int, 2009 Feb

Systemic therapy for advancing or metastatic prostate cancer (STAMPEDE): a multi-arm, multistage randomized controlled trial.

European urology, 2014-06

Might men diagnosed with metastatic prostate cancer benefit from definitive treatment of the primary tumor? A SEER-based study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-04-01

Phase III randomized placebo-controlled trial of two doses of megestrol acetate as treatment for menopausal symptoms in women with breast cancer: Southwest Oncology Group Study 9626.

Lancet Oncol., 2010-02-01

Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: a double-blind, randomised trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-03-20

Phase III comparison of depomedroxyprogesterone acetate to venlafaxine for managing hot flashes: North Central Cancer Treatment Group Trial N99C7.

The Journal of urology, 2005-08

Parenteral medroxyprogesterone for the management of luteinizing hormone releasing hormone induced hot flashes in men with advanced prostate cancer.

Mol Clin Oncol, 2015 May 04

Bee pollen and honey for the alleviation of hot flushes and other menopausal symptoms in breast cancer patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-12-10

Multicenter, randomized, cross-over clinical trial of venlafaxine versus gabapentin for the management of hot flashes in breast cancer survivors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-11-10

Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer.

The Journal of urology, 1999-07

Pilot evaluation of venlafaxine for the treatment of hot flashes in men undergoing androgen ablation therapy for prostate cancer.

Annals of oncology : official journal of the European Society for Medical Oncology, 2009-03

A phase III randomized, double-blind, placebo-controlled trial of gabapentin in the management of hot flashes in men (N00CB).

Mayo Clin Proc, 2004 Oct

Pilot evaluation of paroxetine for treating hot flashes in men.

JNCI Cancer Spectr, 2019 Oct 21

Oxybutynin vs Placebo for Hot Flashes in Women With or Without Breast Cancer: A Randomized, Double-Blind Clinical Trial (ACCRU SC-1603).

N Engl J Med, 1994 Aug 11

Megestrol acetate for the prevention of hot flashes.

The New England journal of medicine, 2018-05-03

Oxybutynin for Hot Flashes Due to Androgen Deprivation in Men.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002-08-01

Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-06-20

Persistent, biologically meaningful prostate cancer after 1 year of androgen ablation and docetaxel treatment.

The Journal of urology, 2002-09

Impact of previous local treatment for prostate cancer on subsequent metastatic disease.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2009-01-15

Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence.

Nature, 2005-12-08

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.

J Clin Oncol, 1999 Jul

Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer: A randomized study.

Lancet, 2015 Jan 3

Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial.

The New England journal of medicine, 2001-12-06

Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer.

Lancet, 2001-09-22

Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial.

Breast Cancer Res. Treat., 2010-02-01

Impact of breast surgery on survival in patients with distant metastases at initial presentation: a systematic review of the literature.

The Journal of urology, 1982-06

Treatment of a metastatic prostate derived tumor with surgery and chemotherapy.

Cancer research, 2000-04-15

Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.

J. Clin. Oncol., 2009-04-01

Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer.

Oncol. Rep., 2015-12-01

Surgical cytoreduction of the primary tumor reduces metastatic progression in a mouse model of prostate cancer.

Nat Commun, 2015-04-01

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

PLoS ONE, 2016-01-01

Does Radiotherapy for the Primary Tumor Benefit Prostate Cancer Patients with Distant Metastasis at Initial Diagnosis?

J. Urol., 2002-04-01

Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis.

Lancet Oncol., 2015 Sep 09

Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial.

European urology, 2018-02

Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.

Lancet, 2018 Oct 18

Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.

Cancer, 2018-03-01

Pooled analysis of stereotactic ablative radiotherapy for primary renal cell carcinoma: A report from the International Radiosurgery Oncology Consortium for Kidney (IROCK).

Radiat Oncol, 2018 Mar 20

A prospective phase I dose-escalation trial of stereotactic ablative radiotherapy (SABR) as an alternative to cytoreductive nephrectomy for inoperable patients with metastatic renal cell carcinoma.

BMC Cancer, 2014 Sep 15

Surveillance or metastasis-directed Therapy for OligoMetastatic Prostate cancer recurrence (STOMP): study protocol for a randomized phase II trial.

JAMA Oncol,

Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer: The ORIOLE Phase 2 Randomized Clinical Trial.

JAMA oncology, 2023 Jun 01

Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial.

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