Iron Homeostasis   

Presuming good medication adherence.

After what time period would you consider adding a second iron chelator?

Does this hold true when the patient has significant inflammation? 

How would your recommendation change if the patient has H63 homozygous mutation?

Ferritin >2200, TSAT >80%

Anemia is secondary to menorrhagia. No gynecologic interventions were possible.

How often do you see non transfusion-dependent thalassemia and how do you approach the treatment?

Although TIBC is negative acute phase reactant, would it be a better indicator of iron deficiency (in combination with ferritin)?

What else would you consider in your differential?

What is the ideal approach for female adolescent athletes if they have complaints of fatigue and dizziness and are diagnosed with mild iron deficiency...

For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?