Myelodysplastic Syndromes   

How do you choose between RIC compared to MAC? Is there evidence for one over the other in an otherwise healthy, young patient? Do you include hypome...

Would a negative NGS eliminate the possibility of MDS? Is bone marrow biopsy indicated in a patient with pancytopenia with a negative NGS panel?

E.g. would you dose-reduce or continue at same dose? Baseline ANC was in the normal range

For instance, if clonal hematopoiesis of indeterminate potential (CHIP) suspected 

Would this change with someone who has a history of thrombosis (e.g. DVT/PE, MI, CVA)? Would this change with someone who is more fit vs more frail?