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Topics:
Hematologic Malignancies • Pediatric Hematology/Oncology • Medical Oncology • Myelodysplastic Syndromes • Internal Medicine • Hematology
How would you approach cytopenias 5 weeks after initial dosing in a young patient with MDS treated with Azacitadine as a bridge to transplant?
E.g. would you dose-reduce or continue at same dose?
Baseline ANC was in the normal range
Answer from: Medical Oncologist at Academic Institution
Bridging with HMA to transplant in MDS patients is a common practice although it did not show improved outcomes. You will definitely have to r/o other potential causes of pancytopenia (i.e., infections, etc). I would repeat a BM A/Bx to make sure that blasts are not increasing (< 20% and preferab...
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