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Topics:
Hematologic Malignancies • Pediatric Hematology/Oncology • Medical Oncology • Leukemia • Hematology
What are the treatment options for relapsed T-ALL in a patient who was nonadherent with AALL and hyper-CVAD regimens?
Is there a role for nelarabine and venetoclax in this setting?
Answer from: at Academic Institution
Regimens to consider with data for R/R T-ALL include:
Nelarabine +/- chemotherapy. There are retrospective data to support adding nelarabine to a chemo backbone (Shimony et al., PMID 36508268 and Shimony et al., PMID 37389830).
HMA + venetoclax (Pinton et al., PMID 37889114 and Cao et al., Blood 2...
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