Rheumatology

Belimumab

Questions discussed in this category

Would you continue belimumab in high risk lupus patients with overlapping scleroderma features with ILD who become pregnant and who are already on HCQ and azathioprine?

1 Answer available

Would you consider belimumab for an SLE patient who has generalized hair thinning, leukopenia (WBC <3), low C3, and markedly positive anti-dsDNA who is otherwise asymptomatic?

The patient is already on hydroxychloroquine.

1 Answer available

Would you use belimumab in a breastfeeding patient with SLE who has persistent joint pain, leukopenia and elevated dsDNA despite HCQ and azathioprine?

3 Answers available

How would you approach initiating belimumab in a patient with serologic evidence of prior hepatitis B infection?

Such as patients with negative Hepatitis B surface antigen and negative viral load but with positive hepatitis b core antibody.

1 Answer available

Would you consider adding voclosporin to belimumab and MMF in the setting of active proteinuria, rather than switching agents?

3 Answers available

Would you have any hesitation to use belimumab in a patient with IgA deficiency?

1 Answer available

Is it okay to use belimumab to treat SLE in a patient who has a history of lymphoma and is on a Bruton's tyrosine kinase inhibitor (such as ibrutinib)?

1 Answer available

Do you think there is a role for belimumab in treating lupus nephritis and if so, in which patients would you considering adding it on?

Did the recently published BLISS-LN trial change your practice?

2 Answers available

Papers discussed in this category

N Engl J Med,

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis.

Lupus, 2013-02

Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus.

Rheumatology (Oxford), 2022 Nov 02

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids.

Rheumatic diseases clinics of North America, 2021 Feb 25

The Categorization of Pain in Systemic Lupus Erythematosus.

Lupus science & medicine, 2023 Jan

Molecular endotypes of type 1 and type 2 SLE.

Arthritis and rheumatism, 2013-07

Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio.

Arthritis care & research, 2016 Jan

Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lupus, 2014 Feb 06

Vitamin D and cutaneous lupus erythematosus: effect of vitamin D replacement on disease severity.

Annals of the rheumatic diseases, 2023 Oct 12

EULAR recommendations for the management of systemic lupus erythematosus: 2023 update.

Arthritis care & research, 2023 Nov 28

Reference Range of Hydroxychloroquine Blood Levels That Can Reduce Odds of Active Lupus and Prevent Flares.

Lupus, 2022 Nov 30

Dilemma of belimumab therapy (dis)continuation during pregnancy: Results of a retrospective study in eudravigilance.

Lupus, 2024 Apr 09

Considering belimumab during pregnancy: A more viable option over time.

Rheumatology

Belimumab

Questions discussed in this category

Papers discussed in this category

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