Is it okay to use belimumab to treat SLE in a patient who has a history of lymphoma and is on a Bruton's tyrosine kinase inhibitor (such as ibrutinib)?  

For patients with ongoing SLE clinical/serologic activity despite ongoing treatment for lymphoma with agents targeting B cell proliferation, it's probably safe to use belimumab if needed in this setting. Thus far, reported experiences and our own using belimumab in patients who have undergone B cell...