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Melanoma/Skin Cancer • Medical Oncology
Do you consider alternate therapy with a different anti-PD1 agent after a patient responds to an anti-CTLA4 +/- anti-PD1 agent but develops serious side effects?
Is there data for switching from nivolumab/ipilimumab to pembrolizumab if a patient develops significant pneumonitis but also had a significant radiographic response?
Answer from: Medical Oncologist at Academic Institution
The short answer is no. Pembro and Nivo are essentailly the same drug and in all the studies, once the patient has developed grade 3 toxicity the treatment is complete because further dosing will result in even more severe toxicty. The only exception is for endocrinopathies which can be managed with...
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