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Do you consider prophylactically increasing eculizumab frequency for pregnant or postpartum PNH patients?
How often would you check labs during pregnancy or postpartum to monitor for worsening hemolysis?
Answer from: at Academic Institution
Yes, there have been several case series and reports indicating that eculizumab may need to be prophylactically increased in dose or frequency (because the pregnancy state may further increase complement activation in PNH patients). This efficacy of eculizumab may be monitored by standard hemolysis ...
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