How would you treat suspected secondary HLH in patients whom etoposide is contraindicated?

No clear inciting etiology found.

Would you consider dexamethasone +/- cytokine blockade (IL-1, IL-6, or IFN-g)? What do you think about the data for using of JAK2 inhibitors + IFN-g?

Answer from: at Community Practice

Thank you for the interesting question. It would be helpful to understand why etoposide is contraindicated. My general approach for these patients is to first ensure that there is no evidence of malignancy as a trigger as you do not want to mask that with steroids (I strongly recommend obtaining a P...

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at University of Pittsburgh
Hello and thank you for this very interesting answ...

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How would you treat suspected secondary HLH in patients whom etoposide is contraindicated?

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