How do you counsel sickle cell patients on the use of G-CSF to treat neutropenia from other causes, like malignancy?

Do you discuss the risk of sickle cell crises with G-CSF? What about for patients with sickle cell trait?

Answer from: at Academic Institution

G-CSF is contraindicated in sickle cell disease. There have been many case reports of severe complications, including death in patients with SCD receiving G-CSF. I would only use it in neutropenic sepsis with transfusion support to prevent vaso-occlusive complications and after a discussion about it...

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Medical Oncologist at Indiana University School of Medicine
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How do you counsel sickle cell patients on the use of G-CSF to treat neutropenia from other causes, like malignancy?

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