How do you counsel sickle cell patients on the use of G-CSF to treat neutropenia from other causes, like malignancy?  

G-CSF is contraindicated in sickle cell disease. There have been many case reports of severe complications, including death in patients with SCD receiving G-CSF. I would only use it in neutropenic sepsis with transfusion support to prevent vaso-occlusive complications and after a discussion about it...