For von Willebrand type 2B, do you expect a decline in platelet count over time as vWF increases with age?  

Von Willebrand factor levels increase with age in normal people and in those with type 1 VWD. There is no or a much lesser degree of VWF rise in variants type 2 and 3.  I would not expect a significant decrease in the platelet count in a patient with type 2B with increasing age, but if it occu...