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Is there specific data on using luspatercept for sickle beta+ thalassemia with transfusion-dependent anemia?
For this subpopulation, are there additional risks such as thrombosis?
Answer from: at Community Practice
There is no data currently on the use of luspatercept in any condition other than beta thalassemia, including HbE-beta thalassemia. It has been studied in the beta thalassemia phenotype, both transfusion-dependent and non-transfusion-dependent (adult data published, pediatric trial underway), b...
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Answer from: at Academic Institution
Sickle beta+ thalassemia does not typically cause transfusion-dependent anemia. The anemia is usually mild or nonexistent in this SCD variant, so if there is severe anemia, I would investigate for other comorbidities. There is no specific data on luspatercept in any of the sickle cell disease subtyp...
Answer from: at Academic Institution
Similarly, I know of no data supporting its use in sickle-beta thalassemia.