Do you consider Randall's plaque as a form of nephrocalcinosis necessitating genetic testing for monogenic kidney stone disorders?
Answer from: at Academic Institution
No. Randall's plaque is the infrastructure of all calcium oxalate kidney stones. It is formed beneath the uroepithelium, due to (according to preliminary research) excess reabsorption of calcium in the thick ascending limb of Henley's loop. it is composed of calcium phosphate and somehow induces the...
I agree that Randall's plaque is a common finding associated with calcium oxalate stones, but it is found in both stone formers and non-stone formers, according to many urologists working in the stone field. The proposed pathway to its formation is plausible. It does not warrant genetic testing. Not...