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Rheumatology • Pediatric Rheumatology • Pulmonary • JIA • ACR 2024 • Continue the Conversation
Do you continue biologics in sJIA patients who develop lung disease on anti IL-1 or anti IL-6 therapies?
This question is part of our collaboration with ACR Convergence 2024 to Continue the Conversation from the meeting. This question was inspired by the session "Pediatric Great Debate – To treat or not to treat SJIA lung disease with biologics" by Dr. @Randall Cron and Dr. @Karen Onel.
Answer from: at Academic Institution
As was mentioned in the debate, "it depends". I also exclusively use weekly SC methotrexate and anakinra to treat sJIA. I likely would not stop anakinra unless there was a clear allergic reaction to the injections. If MAS is an issue, as it often is with sJIA lung disease, then all the more reason t...
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Answer from: at Community Practice
It really does depend. If a child is otherwise doing well, stopping cytokine inhibitors can worsen the underlying disease precipitously putting the child at risk. More often then not in my experience, at the time that lung disease is discovered, the treatments are not controlling t...