Do you de-escalate airway clearance therapies in patients with CF who experience an improvement in mucus production and clearance after CFTR modulator therapy is started?  

De-escalation of airway clearance therapy, and even mucolytic therapy, is a frequently encountered question since the introduction of highly effective modulator therapy. Since the majority of patients no longer have cough or sputum production, the necessity of such therapy is often questioned and it...