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Breast Cancer • Medical Oncology
Do you have a preference for a CDK4/6 inhibitor for first line metastatic HR positive breast cancer in combination with faslodex?
Answer from: Medical Oncologist at Community Practice
I do not have a preference for a CDK 4/6 inhibitor when given with fulvestran for metastatic ER+/Her-2 - breast cancer. Both palbociclib and abemaciclib are approved in combination with fulvestrant. There are differences in terms of dosing, schedule, and side effects. But, these features don't sugge...
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Answer from: Medical Oncologist at Community Practice
There is actually some mature data now on overall survival. The MONARCH 2 clinical trial evaluated the combination of fulvestrant and abemaciclib showing a prolonged median overall survival in both premenopausal and postmenopausal women. The MONALEESA-7 trial has shown an overall survival, but this ...
Answer from: Medical Oncologist at Academic Institution
At ESMO 2019, MONALEESA-3 results were presented; ribociclib added to fulvestrant in first- and second-line setting in post menopausal women showed improvement in OS, and OS reached statistical significance when both subgroups were combined. So, all three agents improve OS when combined with fulvest...