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Do you have any hesitations for combining belimumab with any of the DMARDs in patients with SLE/RA overlap?
Answer from: at Community Practice
The only disease-modifying agents for rheumatic diseases (DMARDs) that I would not use with Benlysta are the Janus kinase inhibitors (tofacitinib, baricitinib, and upadacitinib), which are considered “targeted synthetic DMARDs” (Harrington). We all know these agents to be as strong as bi...
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Answer from: at Academic Institution
I agree with Dr. @Donald E. Thomas.I have used belimumab in combination with most DMARDs (Methotrexate, Mycophenolate, Azathioprine, Hydroxychloroquine) without any safety signals (except an increase in UTI and bronchitis rates in my experience). I have avoided combining belimumab with other biologi...