Do you hold osimertinib when delivering partial or whole brain 3D radiation?   

I typically don't mandate holding osimertinib while administering SRS for brain metastases unless my medical or neuro-oncologist has concerns. In such cases, I might consider delaying the initiation of osimertinib for about a week. Notably, there are two prospective studies (NCT03769103 and NCT03497...