Do you prefer Vancomycin or Daptomycin for gram positive coverage in culture negative prosthetic valve endocarditis considering both Corynebacterium and Enterococcus are notable possible pathogens?  

In recent years, we have transitioned from using Vancomycin to Daptomycin for the treatment of endocarditis, whether it involves a native or prosthetic valve or culture negative. This shift is primarily due to concerns about intolerance rather than Vancomycin resistance. Additionally, recent literat...