Do you provide prophylactic anticoagulation with abemaciclib in the adjuvant setting given known thrombosis risk?   

I don’t generally recommend prophylactic anticoagulation with abema, either in the adjuvant or metastatic setting. There does appear to be a small, but real, incidence of thrombosis associated with abema, as well as the other CDK 4/6 inhibitors. While this risk is quite uncommon, it is importa...