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Topics:
Radiation Oncology • Neuro-Oncology
Do you recommend a washout period for a patient receiving intrathecal chemotherapies prior to/after receiving intracranial SRS?
Does it matter if the patient has a history of WBRT?
Does the specific chemotherapy agent (MTX vs Topotecan vs Triple Intrathecal) change your recommendation?
Do you have a different washout recommendation if you were planning on WBRT?
Answer from: Radiation Oncologist at Academic Institution
There are not a whole lot of clinical data. A couple of general points: 1) some chemotherapy agents, especially methotrexate, are known to increase CNS toxicity of radiation (especially whole brain RT) when used concurrently; 2) intrathecally administrated chemotherapy nonetheless has generally limi...
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