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Do you recommend concurrent cisplatin and gemcitabine with radiotherapy for unresectable vulvar cancer, as described in GOG-279?
Answer from: Radiation Oncologist at Community Practice
We are still doing weekly cisplatinum with a higher dose of RT as there is concern about additional morbidity with the addition of gemzar. Richman et al., PMID 32981696
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Answer from: Radiation Oncologist at Academic Institution
The rates of G4 toxicity with the addition of Gemcitabine are concerning to me. 18 out of 52 patients (34.6%) had G4 toxicity per the initial NRG press release. At the time, I figured a proportion of it was related to dermatitis.Per the recently published JCO paper (Horowitz et al., PMID 38574312) j...