What adjuvant treatment would you recommend for a patient with FIGO 2023 IIIB2 endometrioid endometrial adenocarcinoma (Grade 3, p53mut, MMR proficient), metastatic to the uterine serosa, bilateral ovaries, and anterior peritoneal reflection?
What do you think is the role of radiation for this patient and how should it be timed?
Answer from: Radiation Oncologist at Community Practice
I don't routinely radiate these patients unless they are copy-number low/NSMP subset, in which case I give chemotherapy first and radiation.These are the subset of patients in PORTEC-3 that benefitted from chemotherapy and based on GOG-0258, you can absolutely omit radiation. If this patient was sta...
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Radiation Oncologist at Aurora Medical Center-Kenosha If I may ask, what's the reasoning behind adding r...
Answer from: Radiation Oncologist at Community Practice
For this patient, I would just give cuff brachy between cycles 1-2 if adequately healed, as with peritoneal and ovarian disease patterns of failure don't support EBRT in my eyes.