Do you recommend CSF analysis in young patients with imaging findings consistent with progressive supranuclear palsy?  

This is a difficult question and I'm not experienced enough to give you a great answer. In the end, it depends on the age of onset (age <50 would give me pause), rate of progression, the inclusion of expected PSP symptomology (supranuclear palsy, akinetic-rigid axial parkinsonism, spontaneous ret...